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000127266 0247_ $$2doi$$a10.1016/j.ccell.2015.04.002
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000127266 1001_ $$0P:(DE-He78)a7c1bbac024fa232d9c6b78443328d9d$$aPajtler, Kristian$$b0$$eFirst author$$udkfz
000127266 245__ $$aMolecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.
000127266 260__ $$aCambridge, Mass.$$bCell Press$$c2015
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000127266 520__ $$aEpendymal tumors across age groups are currently classified and graded solely by histopathology. It is, however, commonly accepted that this classification scheme has limited clinical utility based on its lack of reproducibility in predicting patients' outcome. We aimed at establishing a uniform molecular classification using DNA methylation profiling. Nine molecular subgroups were identified in a large cohort of 500 tumors, 3 in each anatomical compartment of the CNS, spine, posterior fossa, supratentorial. Two supratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively. Regarding clinical associations, the molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.
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000127266 650_7 $$2NLM Chemicals$$aAdaptor Proteins, Signal Transducing
000127266 650_7 $$2NLM Chemicals$$aPhosphoproteins
000127266 650_7 $$2NLM Chemicals$$aYAP1 (Yes-associated) protein, human
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000127266 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b3$$udkfz
000127266 7001_ $$0P:(DE-He78)744146d3b5a3df1e0ac555e5bf1ee5cc$$aHovestadt, Volker$$b4$$udkfz
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000127266 7001_ $$aWani, Khalida$$b6
000127266 7001_ $$aTatevossian, Ruth$$b7
000127266 7001_ $$aPunchihewa, Chandanamali$$b8
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000127266 7001_ $$aReimand, Jüri$$b10
000127266 7001_ $$aWarnatz, Hans-Jörg$$b11
000127266 7001_ $$aRyzhova, Marina$$b12
000127266 7001_ $$aMack, Steve$$b13
000127266 7001_ $$aRamaswamy, Vijay$$b14
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000127266 7001_ $$0P:(DE-He78)c16f26d78779ca1c53b6939e7a5ce788$$aHuang, Zhiqin$$b19$$udkfz
000127266 7001_ $$avan Sluis, Peter$$b20
000127266 7001_ $$aVolckmann, Richard$$b21
000127266 7001_ $$aKoster, Jan$$b22
000127266 7001_ $$aVersteeg, Rogier$$b23
000127266 7001_ $$aFults, Daniel$$b24
000127266 7001_ $$aToledano, Helen$$b25
000127266 7001_ $$aAvigad, Smadar$$b26
000127266 7001_ $$aHoffman, Lindsey M$$b27
000127266 7001_ $$aDonson, Andrew M$$b28
000127266 7001_ $$aForeman, Nicholas$$b29
000127266 7001_ $$aHewer, Ekkehard$$b30
000127266 7001_ $$aZitterbart, Karel$$b31
000127266 7001_ $$aGilbert, Mark$$b32
000127266 7001_ $$aArmstrong, Terri S$$b33
000127266 7001_ $$aGupta, Nalin$$b34
000127266 7001_ $$aAllen, Jeffrey C$$b35
000127266 7001_ $$aKarajannis, Matthias A$$b36
000127266 7001_ $$aZagzag, David$$b37
000127266 7001_ $$aHasselblatt, Martin$$b38
000127266 7001_ $$aKulozik, Andreas E$$b39
000127266 7001_ $$0P:(DE-He78)143af26de9d57bf624771616318aaf7c$$aWitt, Olaf$$b40$$udkfz
000127266 7001_ $$aCollins, V Peter$$b41
000127266 7001_ $$avon Hoff, Katja$$b42
000127266 7001_ $$aRutkowski, Stefan$$b43
000127266 7001_ $$aPietsch, Torsten$$b44
000127266 7001_ $$aBader, Gary$$b45
000127266 7001_ $$aYaspo, Marie-Laure$$b46
000127266 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$avon Deimling, Andreas$$b47$$udkfz
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000127266 7001_ $$aTaylor, Michael D$$b49
000127266 7001_ $$aGilbertson, Richard$$b50
000127266 7001_ $$aEllison, David W$$b51
000127266 7001_ $$aAldape, Kenneth$$b52
000127266 7001_ $$0P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93$$aKorshunov, Andrey$$b53$$udkfz
000127266 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b54$$udkfz
000127266 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b55$$eLast author$$udkfz
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