TY  - JOUR
AU  - Pajtler, Kristian
AU  - Witt, Hendrik
AU  - Sill, Martin
AU  - Jones, David
AU  - Hovestadt, Volker
AU  - Kratochwil, Fabian
AU  - Wani, Khalida
AU  - Tatevossian, Ruth
AU  - Punchihewa, Chandanamali
AU  - Johann, Pascal
AU  - Reimand, Jüri
AU  - Warnatz, Hans-Jörg
AU  - Ryzhova, Marina
AU  - Mack, Steve
AU  - Ramaswamy, Vijay
AU  - Capper, David
AU  - Schweizer, Leonille
AU  - Sieber, Laura
AU  - Wittmann, Andrea
AU  - Huang, Zhiqin
AU  - van Sluis, Peter
AU  - Volckmann, Richard
AU  - Koster, Jan
AU  - Versteeg, Rogier
AU  - Fults, Daniel
AU  - Toledano, Helen
AU  - Avigad, Smadar
AU  - Hoffman, Lindsey M
AU  - Donson, Andrew M
AU  - Foreman, Nicholas
AU  - Hewer, Ekkehard
AU  - Zitterbart, Karel
AU  - Gilbert, Mark
AU  - Armstrong, Terri S
AU  - Gupta, Nalin
AU  - Allen, Jeffrey C
AU  - Karajannis, Matthias A
AU  - Zagzag, David
AU  - Hasselblatt, Martin
AU  - Kulozik, Andreas E
AU  - Witt, Olaf
AU  - Collins, V Peter
AU  - von Hoff, Katja
AU  - Rutkowski, Stefan
AU  - Pietsch, Torsten
AU  - Bader, Gary
AU  - Yaspo, Marie-Laure
AU  - von Deimling, Andreas
AU  - Lichter, Peter
AU  - Taylor, Michael D
AU  - Gilbertson, Richard
AU  - Ellison, David W
AU  - Aldape, Kenneth
AU  - Korshunov, Andrey
AU  - Kool, Marcel
AU  - Pfister, Stefan
TI  - Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.
JO  - Cancer cell
VL  - 27
IS  - 5
SN  - 1535-6108
CY  - Cambridge, Mass.
PB  - Cell Press
M1  - DKFZ-2017-03291
SP  - 728 - 743
PY  - 2015
AB  - Ependymal tumors across age groups are currently classified and graded solely by histopathology. It is, however, commonly accepted that this classification scheme has limited clinical utility based on its lack of reproducibility in predicting patients' outcome. We aimed at establishing a uniform molecular classification using DNA methylation profiling. Nine molecular subgroups were identified in a large cohort of 500 tumors, 3 in each anatomical compartment of the CNS, spine, posterior fossa, supratentorial. Two supratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively. Regarding clinical associations, the molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.
KW  - Adaptor Proteins, Signal Transducing (NLM Chemicals)
KW  - Phosphoproteins (NLM Chemicals)
KW  - YAP1 (Yes-associated) protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:25965575
C2  - pmc:PMC4712639
DO  - DOI:10.1016/j.ccell.2015.04.002
UR  - https://inrepo02.dkfz.de/record/127266
ER  -