000127270 001__ 127270
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000127270 0247_ $$2ISSN$$a1078-8956
000127270 0247_ $$2ISSN$$a1546-170X
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000127270 037__ $$aDKFZ-2017-03295
000127270 041__ $$aeng
000127270 082__ $$a610
000127270 1001_ $$0P:(DE-HGF)0$$aPapathanasiou, Stamatis$$b0
000127270 245__ $$aTumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18.
000127270 260__ $$aNew York, NY$$bNature America Inc.$$c2015
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000127270 520__ $$aTumor necrosis factor-α (TNF-α), one of the major stress-induced proinflammatory cytokines, is upregulated in the heart after tissue injury, and its sustained expression can contribute to the development of heart failure. Whether TNF-α also exerts cytoprotective effects in heart failure is not known. Here we provide evidence for a cardioprotective function of TNF-α in a genetic heart failure model, desmin-deficient mice. The cardioprotective effects of TNF-α are a consequence of nuclear factor-κB (NF-κB)-mediated ectopic expression in cardiomyocytes of keratin 8 (K8) and keratin 18 (K18), two epithelial-specific intermediate filament proteins. In cardiomyocytes, K8 and K18 (K8/K18) formed an alternative cytoskeletal network that localized mainly at intercalated discs (IDs) and conferred cardioprotection by maintaining normal ID structure and mitochondrial integrity and function. Ectopic induction of K8/K18 expression in cardiomyocytes also occurred in other genetic and experimental models of heart failure. Loss of the K8/K18 network resulted in a maladaptive cardiac phenotype following transverse aortic constriction. In human failing myocardium, where TNF-α expression is upregulated, K8/K18 were also ectopically expressed and localized primarily at IDs, which did not contain detectable amounts of desmin. Thus, TNF-α- and NF-κB-mediated formation of an alternative, stress-induced intermediate filament cytoskeleton has cardioprotective function in mice and potentially in humans.
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000127270 650_7 $$2NLM Chemicals$$aDesmin
000127270 650_7 $$2NLM Chemicals$$aKeratin-18
000127270 650_7 $$2NLM Chemicals$$aKeratin-8
000127270 650_7 $$2NLM Chemicals$$aNF-kappa B
000127270 650_7 $$2NLM Chemicals$$aTumor Necrosis Factor-alpha
000127270 7001_ $$0P:(DE-HGF)0$$aRickelt, Steffen$$b1
000127270 7001_ $$aSoriano, Maria Eugenia$$b2
000127270 7001_ $$aSchips, Tobias G$$b3
000127270 7001_ $$aMaier, Harald J$$b4
000127270 7001_ $$aDavos, Constantinos H$$b5
000127270 7001_ $$aVarela, Aimilia$$b6
000127270 7001_ $$aKaklamanis, Loukas$$b7
000127270 7001_ $$aMann, Douglas L$$b8
000127270 7001_ $$aCapetanaki, Yassemi$$b9
000127270 773__ $$0PERI:(DE-600)1484517-9$$a10.1038/nm.3925$$gVol. 21, no. 9, p. 1076 - 1084$$n9$$p1076 - 1084$$tNature medicine$$v21$$x1546-170X$$y2015
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000127270 9141_ $$y2015
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