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| 001 | 127270 | ||
| 005 | 20240228140915.0 | ||
| 024 | 7 | _ | |a 10.1038/nm.3925 |2 doi |
| 024 | 7 | _ | |a pmid:26280121 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC5419049 |2 pmc |
| 024 | 7 | _ | |a 1078-8956 |2 ISSN |
| 024 | 7 | _ | |a 1546-170X |2 ISSN |
| 024 | 7 | _ | |a altmetric:4405412 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-03295 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Papathanasiou, Stamatis |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18. |
| 260 | _ | _ | |a New York, NY |c 2015 |b Nature America Inc. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1508309346_2417 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Tumor necrosis factor-α (TNF-α), one of the major stress-induced proinflammatory cytokines, is upregulated in the heart after tissue injury, and its sustained expression can contribute to the development of heart failure. Whether TNF-α also exerts cytoprotective effects in heart failure is not known. Here we provide evidence for a cardioprotective function of TNF-α in a genetic heart failure model, desmin-deficient mice. The cardioprotective effects of TNF-α are a consequence of nuclear factor-κB (NF-κB)-mediated ectopic expression in cardiomyocytes of keratin 8 (K8) and keratin 18 (K18), two epithelial-specific intermediate filament proteins. In cardiomyocytes, K8 and K18 (K8/K18) formed an alternative cytoskeletal network that localized mainly at intercalated discs (IDs) and conferred cardioprotection by maintaining normal ID structure and mitochondrial integrity and function. Ectopic induction of K8/K18 expression in cardiomyocytes also occurred in other genetic and experimental models of heart failure. Loss of the K8/K18 network resulted in a maladaptive cardiac phenotype following transverse aortic constriction. In human failing myocardium, where TNF-α expression is upregulated, K8/K18 were also ectopically expressed and localized primarily at IDs, which did not contain detectable amounts of desmin. Thus, TNF-α- and NF-κB-mediated formation of an alternative, stress-induced intermediate filament cytoskeleton has cardioprotective function in mice and potentially in humans. |
| 536 | _ | _ | |a 311 - Signalling pathways, cell and tumor biology (POF3-311) |0 G:(DE-HGF)POF3-311 |c POF3-311 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Desmin |2 NLM Chemicals |
| 650 | _ | 7 | |a Keratin-18 |2 NLM Chemicals |
| 650 | _ | 7 | |a Keratin-8 |2 NLM Chemicals |
| 650 | _ | 7 | |a NF-kappa B |2 NLM Chemicals |
| 650 | _ | 7 | |a Tumor Necrosis Factor-alpha |2 NLM Chemicals |
| 700 | 1 | _ | |a Rickelt, Steffen |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Soriano, Maria Eugenia |b 2 |
| 700 | 1 | _ | |a Schips, Tobias G |b 3 |
| 700 | 1 | _ | |a Maier, Harald J |b 4 |
| 700 | 1 | _ | |a Davos, Constantinos H |b 5 |
| 700 | 1 | _ | |a Varela, Aimilia |b 6 |
| 700 | 1 | _ | |a Kaklamanis, Loukas |b 7 |
| 700 | 1 | _ | |a Mann, Douglas L |b 8 |
| 700 | 1 | _ | |a Capetanaki, Yassemi |b 9 |
| 773 | _ | _ | |a 10.1038/nm.3925 |g Vol. 21, no. 9, p. 1076 - 1084 |0 PERI:(DE-600)1484517-9 |n 9 |p 1076 - 1084 |t Nature medicine |v 21 |y 2015 |x 1546-170X |
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