%0 Journal Article
%A Peifer, Martin
%A Hertwig, Falk
%A Roels, Frederik
%A Dreidax, Daniel
%A Gartlgruber, Moritz
%A Menon, Roopika
%A Krämer, Andrea
%A Roncaioli, Justin L
%A Sand, Frederik
%A Heuckmann, Johannes M
%A Ikram, Fakhera
%A Schmidt, Rene
%A Ackermann, Sandra
%A Engesser, Anne
%A Kahlert, Yvonne
%A Vogel, Wenzel
%A Altmüller, Janine
%A Nürnberg, Peter
%A Thierry-Mieg, Jean
%A Thierry-Mieg, Danielle
%A Mariappan, Aruljothi
%A Heynck, Stefanie
%A Mariotti, Erika
%A Henrich, Kai-Oliver
%A Gloeckner, Christian
%A Bosco, Graziella
%A Leuschner, Ivo
%A Schweiger, Michal R
%A Savelyeva, Larissa
%A Watkins, Simon C
%A Shao, Chunxuan
%A Bell, Emma
%A Höfer, Thomas
%A Achter, Viktor
%A Lang, Ulrich
%A Theissen, Jessica
%A Volland, Ruth
%A Saadati, Maral
%A Eggert, Angelika
%A de Wilde, Bram
%A Berthold, Frank
%A Peng, Zhiyu
%A Zhao, Chen
%A Shi, Leming
%A Ortmann, Monika
%A Büttner, Reinhard
%A Perner, Sven
%A Hero, Barbara
%A Schramm, Alexander
%A Schulte, Johannes
%A Herrmann, Carl
%A O'Sullivan, Roderick J
%A Westermann, Frank
%A Thomas, Roman K
%A Fischer, Matthias
%T Telomerase activation by genomic rearrangements in high-risk neuroblastoma.
%J Nature 
%V 526
%N 7575
%@ 1476-4687
%C London [u.a.]
%I Nature Publ. Group
%M DKFZ-2017-03306
%P 700 - 704
%D 2015
%X Neuroblastoma is a malignant paediatric tumour of the sympathetic nervous system. Roughly half of these tumours regress spontaneously or are cured by limited therapy. By contrast, high-risk neuroblastomas have an unfavourable clinical course despite intensive multimodal treatment, and their molecular basis has remained largely elusive. Here we have performed whole-genome sequencing of 56 neuroblastomas (high-risk, n = 39; low-risk, n = 17) and discovered recurrent genomic rearrangements affecting a chromosomal region at 5p15.33 proximal of the telomerase reverse transcriptase gene (TERT). These rearrangements occurred only in high-risk neuroblastomas (12/39, 31
%K Chromatin (NLM Chemicals)
%K MYCN protein, human (NLM Chemicals)
%K N-Myc Proto-Oncogene Protein (NLM Chemicals)
%K Nuclear Proteins (NLM Chemicals)
%K Oncogene Proteins (NLM Chemicals)
%K RNA, Messenger (NLM Chemicals)
%K TERT protein, human (NLM Chemicals)
%K Telomerase (NLM Chemicals)
%K DNA Helicases (NLM Chemicals)
%K ATRX protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:26466568
%2 pmc:PMC4881306
%R 10.1038/nature14980
%U https://inrepo02.dkfz.de/record/127281