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@ARTICLE{Pesch:127291,
      author       = {M. Pesch and I. Schultheiß and K. Klopffleisch and J. F.
                      Uhrig and M. Koegl$^*$ and C. S. Clemen and R. Simon and S.
                      Weidtkamp-Peters and M. Hülskamp},
      title        = {{TRANSPARENT} {TESTA} {GLABRA}1 and {GLABRA}1 {C}ompete for
                      {B}inding to {GLABRA}3 in {A}rabidopsis.},
      journal      = {Plant physiology},
      volume       = {168},
      number       = {2},
      issn         = {1532-2548},
      address      = {Rockville, Md.},
      publisher    = {Soc.},
      reportid     = {DKFZ-2017-03316},
      pages        = {584 - 597},
      year         = {2015},
      abstract     = {The MBW (for R2R3MYB, basic helix-loop-helix [bHLH], and
                      WD40) genes comprise an evolutionarily conserved gene
                      cassette that regulates several traits such as
                      (pro)anthocyanin and anthocyanin biosynthesis and epidermal
                      cell differentiation in plants. Trichome differentiation in
                      Arabidopsis (Arabidopsis thaliana) is governed by GLABRA1
                      (GL1; R2R3MYB), GL3 (bHLH), and transparent TESTA GLABRA1
                      (TTG1; WD40). They are thought to form a trimeric complex
                      that acts as a transcriptional activation complex. We
                      provide evidence that these three MBW proteins form either
                      GL1 GL3 or GL3 TTG1 dimers. The formation of each dimer is
                      counteracted by the respective third protein in yeast
                      three-hybrid assays, pulldown experiments
                      (luminescence-based mammalian interactome), and fluorescence
                      lifetime imaging microscopy-fluorescence resonance energy
                      transfer studies. We further show that two target promoters,
                      Triptychon (TRY) and CAPRICE (CPC), are differentially
                      regulated: GL1 represses the activation of the TRY promoter
                      by GL3 and TTG1, and TTG1 suppresses the activation of the
                      CPC promoter by GL1 and GL3. Our data suggest that the
                      transcriptional activation by the MBW complex involves
                      alternative complex formation and that the two dimers can
                      differentially regulate downstream genes.},
      keywords     = {Arabidopsis Proteins (NLM Chemicals) / Basic
                      Helix-Loop-Helix Transcription Factors (NLM Chemicals) / CPC
                      protein, Arabidopsis (NLM Chemicals) / DNA-Binding Proteins
                      (NLM Chemicals) / GL3 protein, Arabidopsis (NLM Chemicals) /
                      Proto-Oncogene Proteins c-myb (NLM Chemicals) / TTG1
                      protein, Arabidopsis (NLM Chemicals) / GL1 protein,
                      Arabidopsis (NLM Chemicals)},
      cin          = {W150},
      ddc          = {580},
      cid          = {I:(DE-He78)W150-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25926482},
      pmc          = {pmc:PMC4453790},
      doi          = {10.1104/pp.15.00328},
      url          = {https://inrepo02.dkfz.de/record/127291},
}