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@ARTICLE{Rabionet:127335,
      author       = {M. Rabionet$^*$ and A. Bayerle$^*$ and R. Jennemann$^*$ and
                      H. Heid$^*$ and J. Fuchser and C. Marsching$^*$ and S.
                      Porubsky and C. Bolenz and F. Guillou and H.-J. Gröne$^*$
                      and K. Gorgas and R. Sandhoff$^*$},
      title        = {{M}ale meiotic cytokinesis requires ceramide synthase
                      3-dependent sphingolipids with unique membrane anchors.},
      journal      = {Human molecular genetics},
      volume       = {24},
      number       = {17},
      issn         = {1460-2083},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2017-03360},
      pages        = {4792 - 4808},
      year         = {2015},
      abstract     = {Somatic cell cytokinesis was shown to involve the insertion
                      of sphingolipids (SLs) to midbodies prior to abscission.
                      Spermatogenic midbodies transform into stable intercellular
                      bridges (ICBs) connecting clonal daughter cells in a
                      syncytium. This process requires specialized SL structures.
                      (1) Using high resolution-mass spectrometric imaging, we
                      show in situ a biphasic pattern of SL synthesis with
                      testis-specific anchors. This pattern correlates with and
                      depends on ceramide synthase 3 (CerS3) localization in both,
                      pachytene spermatocytes until completion of meiosis and
                      elongating spermatids. (2) Blocking the pathways to germ
                      cell-specific ceramides (CerS3-KO) and further to
                      glycosphingolipids (glucosylceramide synthase-KO) in mice
                      highlights the need for special SLs for spermatid ICB
                      stability. In contrast to somatic mitosis these SLs require
                      ultra-long polyunsaturated anchors with unique
                      physico-chemical properties, which can only be provided by
                      CerS3. Loss of these anchors causes enhanced apoptosis
                      during meiosis, formation of multinuclear giant cells and
                      spermatogenic arrest. Hence, testis-specific SLs, which we
                      also link to CerS3 in human testis, are quintessential for
                      male fertility.},
      keywords     = {Fatty Acids (NLM Chemicals) / RNA, Messenger (NLM
                      Chemicals) / Sphingolipids (NLM Chemicals) / LASS3 protein,
                      mouse (NLM Chemicals) / Sphingosine N-Acyltransferase (NLM
                      Chemicals)},
      cin          = {G131 / G130 / A991},
      ddc          = {570},
      cid          = {I:(DE-He78)G131-20160331 / I:(DE-He78)G130-20160331 /
                      I:(DE-He78)A991-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26045466},
      doi          = {10.1093/hmg/ddv204},
      url          = {https://inrepo02.dkfz.de/record/127335},
}