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000127346 037__ $$aDKFZ-2017-03371
000127346 041__ $$aeng
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000127346 1001_ $$aRadujkovic, Aleksandar$$b0
000127346 245__ $$aPre-transplant weight loss predicts inferior outcome after allogeneic stem cell transplantation in patients with myelodysplastic syndrome.
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000127346 520__ $$aAllogeneic stem cell transplantation (alloSCT) represents a curative therapeutic option for patients with myelodysplastic syndrome (MDS), but relapse and non-relapse mortality (NRM) limit treatment efficacy. Based on our previous observation in acute myeloid leukemia we investigated the impact of pre-transplant weight loss on post-transplant outcome in MDS patients. A total of 111 patients diagnosed with MDS according to WHO criteria transplanted between 2000 and 2012 in three different transplant centers were included into the analysis. Data on weight loss were collected from medical records prior to conditioning therapy and 3-6 months earlier. Patient, disease and transplant characteristics did not differ between patients with weight loss (2-5%, n = 17; > 5%, n = 17) and those without (n = 77). In a mixed effect model, weight loss was associated with higher risk MDS (p = 0.046). In multivariable analyses, pre-transplant weight loss exceeding 5% was associated with a higher incidence of relapse (p < 0.001) and NRM (p = 0.007). Pre-transplant weight loss of 2-5% and > 5% were independent predictors of worse disease-free (p = 0.023 and p < 0.001, respectively) and overall survival (p = 0.043 and p < 0.001, respectively). Our retrospective study suggests that MDS patients losing weight prior to alloSCT have an inferior outcome after transplantation. Prospective studies addressing pre-transplant nutritional interventions are highly warranted.
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000127346 7001_ $$0P:(DE-He78)ecb33fb615e08035fdcefcaebfdff8f0$$aBecker, Natalia$$b1$$udkfz
000127346 7001_ $$0P:(DE-He78)e15dfa1260625c69d6690a197392a994$$aBenner, Axel$$b2$$udkfz
000127346 7001_ $$aPenack, Olaf$$b3
000127346 7001_ $$aPlatzbecker, Uwe$$b4
000127346 7001_ $$aStölzel, Friedrich$$b5
000127346 7001_ $$aBornhäuser, Martin$$b6
000127346 7001_ $$aHegenbart, Ute$$b7
000127346 7001_ $$aHo, Anthony D$$b8
000127346 7001_ $$aDreger, Peter$$b9
000127346 7001_ $$aLuft, Thomas$$b10
000127346 773__ $$0PERI:(DE-600)2560162-3$$a10.18632/oncotarget.4805$$gVol. 6, no. 33$$n33$$p7406-7420$$tOncoTarget$$v6$$x1949-2553$$y2015
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000127346 9141_ $$y2015
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