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@ARTICLE{Radujkovic:127346,
      author       = {A. Radujkovic and N. Becker$^*$ and A. Benner$^*$ and O.
                      Penack and U. Platzbecker and F. Stölzel and M. Bornhäuser
                      and U. Hegenbart and A. D. Ho and P. Dreger and T. Luft},
      title        = {{P}re-transplant weight loss predicts inferior outcome
                      after allogeneic stem cell transplantation in patients with
                      myelodysplastic syndrome.},
      journal      = {OncoTarget},
      volume       = {6},
      number       = {33},
      issn         = {1949-2553},
      address      = {[S.l.]},
      publisher    = {Impact Journals LLC},
      reportid     = {DKFZ-2017-03371},
      pages        = {7406-7420},
      year         = {2015},
      abstract     = {Allogeneic stem cell transplantation (alloSCT) represents a
                      curative therapeutic option for patients with
                      myelodysplastic syndrome (MDS), but relapse and non-relapse
                      mortality (NRM) limit treatment efficacy. Based on our
                      previous observation in acute myeloid leukemia we
                      investigated the impact of pre-transplant weight loss on
                      post-transplant outcome in MDS patients. A total of 111
                      patients diagnosed with MDS according to WHO criteria
                      transplanted between 2000 and 2012 in three different
                      transplant centers were included into the analysis. Data on
                      weight loss were collected from medical records prior to
                      conditioning therapy and 3-6 months earlier. Patient,
                      disease and transplant characteristics did not differ
                      between patients with weight loss $(2-5\%,$ n = 17; > $5\%,$
                      n = 17) and those without (n = 77). In a mixed effect model,
                      weight loss was associated with higher risk MDS (p = 0.046).
                      In multivariable analyses, pre-transplant weight loss
                      exceeding $5\%$ was associated with a higher incidence of
                      relapse (p < 0.001) and NRM (p = 0.007). Pre-transplant
                      weight loss of $2-5\%$ and > $5\%$ were independent
                      predictors of worse disease-free (p = 0.023 and p < 0.001,
                      respectively) and overall survival (p = 0.043 and p < 0.001,
                      respectively). Our retrospective study suggests that MDS
                      patients losing weight prior to alloSCT have an inferior
                      outcome after transplantation. Prospective studies
                      addressing pre-transplant nutritional interventions are
                      highly warranted.},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26360778},
      pmc          = {pmc:PMC4741512},
      doi          = {10.18632/oncotarget.4805},
      url          = {https://inrepo02.dkfz.de/record/127346},
}