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| 001 | 127364 | ||
| 005 | 20240228140922.0 | ||
| 024 | 7 | _ | |a 10.1172/JCI74894 |2 doi |
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| 024 | 7 | _ | |a 0021-9738 |2 ISSN |
| 024 | 7 | _ | |a 1558-8238 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2017-03389 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Reissfelder, Christoph |b 0 |
| 245 | _ | _ | |a Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis. |
| 260 | _ | _ | |a Ann Arbor, Mich. |c 2015 |b ASCJ |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521638859_922 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The composition of tumor-targeted T cell infiltrates is a major prognostic factor in colorectal cancer (CRC) outcome; however, the functional role of these populations in prolonging patient survival remains unclear. Here, we evaluated 190 patients with CRC for the presence of functionally active tumor-infiltrating lymphocytes (TILs), the tumor specificity of these TILs, and the correlation between patient TILs and long-term survival. Using intracytoplasmic cytokine staining in conjunction with HLA multimers loaded with tumor peptide and antigen-specific cytokine secretion assays, we determined that TNF-α expression delineates a population of tumor antigen-specific (TA-specific) cytotoxic T lymphocytes (CTLs) present within tumors from patients with CRC. Upregulation of TNF-α expression in TILs strongly correlated with an increase in the total amount of intratumoral TNF-α, which is indicative of tumor-specific CTL activity. Moreover, a retrospective multivariate analysis of 102 patients with CRC, which had multiple immune parameters evaluated, revealed that increased TNF-α concentration was an independent prognostic factor. Together, these results indicate that the prognostic impact of T cell infiltrates for CRC maybe largely based on subpopulations of active TA-specific T cells within the tumor, suggesting causal implication for these cells in patient survival. Additionally, these results support the use of intratumoral TNF-α, which is indicative of T cell function, as a prognostic parameter for CRC. |
| 536 | _ | _ | |a 314 - Tumor immunology (POF3-314) |0 G:(DE-HGF)POF3-314 |c POF3-314 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Neoplasm Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a TNF protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Tumor Necrosis Factor-alpha |2 NLM Chemicals |
| 700 | 1 | _ | |a Stamova, Slava |b 1 |
| 700 | 1 | _ | |a Gossmann, Christina |b 2 |
| 700 | 1 | _ | |a Braun, Marion |b 3 |
| 700 | 1 | _ | |a Bonertz, Andreas |b 4 |
| 700 | 1 | _ | |a Walliczek, Ute |b 5 |
| 700 | 1 | _ | |a Grimm, Mario |b 6 |
| 700 | 1 | _ | |a Rahbari, Nuh N |b 7 |
| 700 | 1 | _ | |a Koch, Moritz |b 8 |
| 700 | 1 | _ | |a Saadati, Maral |0 P:(DE-He78)609d3f1c1420bf59b2332eeab889cb74 |b 9 |u dkfz |
| 700 | 1 | _ | |a Benner, Axel |0 P:(DE-He78)e15dfa1260625c69d6690a197392a994 |b 10 |u dkfz |
| 700 | 1 | _ | |a Büchler, Markus W |b 11 |
| 700 | 1 | _ | |a Jäger, Dirk |b 12 |
| 700 | 1 | _ | |a Halama, Niels |b 13 |
| 700 | 1 | _ | |a Khazaie, Khashayarsha |b 14 |
| 700 | 1 | _ | |a Weitz, Jürgen |b 15 |
| 700 | 1 | _ | |a Beckhove, Philipp |0 P:(DE-He78)1732377f6242a18280bc6aaa196988d1 |b 16 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1172/JCI74894 |g Vol. 125, no. 2, p. 739 - 751 |0 PERI:(DE-600)2018375-6 |n 2 |p 739 - 751 |t The @journal of clinical investigation |v 125 |y 2015 |x 0021-9738 |
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