%0 Journal Article
%A Reuss, David E
%A Kratz, Annekathrin
%A Sahm, Felix
%A Capper, David
%A Schrimpf, Daniel
%A Koelsche, Christian
%A Hovestadt, Volker
%A Bewerunge-Hudler, Melanie
%A Jones, David
%A Schittenhelm, Jens
%A Mittelbronn, Michel
%A Rushing, Elisabeth
%A Simon, Matthias
%A Westphal, Manfred
%A Unterberg, Andreas
%A Platten, Michael
%A Paulus, Werner
%A Reifenberger, Guido
%A Tonn, Joerg-Christian
%A Aldape, Kenneth
%A Pfister, Stefan
%A Korshunov, Andrey
%A Weller, Michael
%A Herold-Mende, Christel
%A Wick, Wolfgang
%A Brandner, Sebastian
%A von Deimling, Andreas
%T Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities.
%J Acta neuropathologica
%V 130
%N 3
%@ 1432-0533
%C Berlin
%I Springer
%M DKFZ-2017-03396
%P 407 - 417
%D 2015
%X IDH wild type (IDHwt) anaplastic astrocytomas WHO grade III (AA III) are associated with poor outcome. To address the possibilities of molecular subsets among astrocytoma or of diagnostic reclassification, we analyzed a series of 160 adult IDHwt tumors comprising 120 AA III and 40 diffuse astrocytomas WHO grade II (A II) for molecular hallmark alterations and established methylation and copy number profiles. Based on molecular profiles and hallmark alterations the tumors could be grouped into four major sets. 124/160 (78 
%K Biomarkers, Tumor (NLM Chemicals)
%K Isocitrate Dehydrogenase (NLM Chemicals)
%K isocitrate dehydrogenase 2, human (NLM Chemicals)
%K IDH1 protein, human (NLM Chemicals)
%K TERT protein, human (NLM Chemicals)
%K Telomerase (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:26087904
%R 10.1007/s00401-015-1454-8
%U https://inrepo02.dkfz.de/record/127371