TY  - JOUR
AU  - Reuss, David E
AU  - Kratz, Annekathrin
AU  - Sahm, Felix
AU  - Capper, David
AU  - Schrimpf, Daniel
AU  - Koelsche, Christian
AU  - Hovestadt, Volker
AU  - Bewerunge-Hudler, Melanie
AU  - Jones, David
AU  - Schittenhelm, Jens
AU  - Mittelbronn, Michel
AU  - Rushing, Elisabeth
AU  - Simon, Matthias
AU  - Westphal, Manfred
AU  - Unterberg, Andreas
AU  - Platten, Michael
AU  - Paulus, Werner
AU  - Reifenberger, Guido
AU  - Tonn, Joerg-Christian
AU  - Aldape, Kenneth
AU  - Pfister, Stefan
AU  - Korshunov, Andrey
AU  - Weller, Michael
AU  - Herold-Mende, Christel
AU  - Wick, Wolfgang
AU  - Brandner, Sebastian
AU  - von Deimling, Andreas
TI  - Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities.
JO  - Acta neuropathologica
VL  - 130
IS  - 3
SN  - 1432-0533
CY  - Berlin
PB  - Springer
M1  - DKFZ-2017-03396
SP  - 407 - 417
PY  - 2015
AB  - IDH wild type (IDHwt) anaplastic astrocytomas WHO grade III (AA III) are associated with poor outcome. To address the possibilities of molecular subsets among astrocytoma or of diagnostic reclassification, we analyzed a series of 160 adult IDHwt tumors comprising 120 AA III and 40 diffuse astrocytomas WHO grade II (A II) for molecular hallmark alterations and established methylation and copy number profiles. Based on molecular profiles and hallmark alterations the tumors could be grouped into four major sets. 124/160 (78 
KW  - Biomarkers, Tumor (NLM Chemicals)
KW  - Isocitrate Dehydrogenase (NLM Chemicals)
KW  - isocitrate dehydrogenase 2, human (NLM Chemicals)
KW  - IDH1 protein, human (NLM Chemicals)
KW  - TERT protein, human (NLM Chemicals)
KW  - Telomerase (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26087904
DO  - DOI:10.1007/s00401-015-1454-8
UR  - https://inrepo02.dkfz.de/record/127371
ER  -