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| Home > Publications database > The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage. > print |
| Home > Publications database > The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage. > print |
| 001 | 127374 | ||
| 005 | 20240228140923.0 | ||
| 024 | 7 | _ | |a 10.1074/jbc.M114.628982 |2 doi |
| 024 | 7 | _ | |a pmid:25944899 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC4505402 |2 pmc |
| 024 | 7 | _ | |a 0021-9258 |2 ISSN |
| 024 | 7 | _ | |a 1083-351X |2 ISSN |
| 037 | _ | _ | |a DKFZ-2017-03399 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Reuven, Nina |b 0 |
| 245 | _ | _ | |a The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage. |
| 260 | _ | _ | |a Bethesda, Md. |c 2015 |b Soc. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1508310898_2432 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The non-receptor tyrosine kinase c-Abl is activated in response to DNA damage and induces p73-dependent apoptosis. Here, we investigated c-Abl regulation of the homeodomain-interacting protein kinase 2 (HIPK2), an important regulator of p53-dependent apoptosis. c-Abl phosphorylated HIPK2 at several sites, and phosphorylation by c-Abl protected HIPK2 from degradation mediated by the ubiquitin E3 ligase Siah-1. c-Abl and HIPK2 synergized in activating p53 on apoptotic promoters in a reporter assay, and c-Abl was required for endogenous HIPK2 accumulation and phosphorylation of p53 at Ser(46) in response to DNA damage by γ- and UV radiation. Accumulation of HIPK2 in nuclear speckles and association with promyelocytic leukemia protein (PML) in response to DNA damage were also dependent on c-Abl activity. At high cell density, the Hippo pathway inhibits DNA damage-induced c-Abl activation. Under this condition, DNA damage-induced HIPK2 accumulation, phosphorylation of p53 at Ser(46), and apoptosis were attenuated. These data demonstrate a new mechanism for the induction of DNA damage-induced apoptosis by c-Abl and illustrate network interactions between serine/threonine and tyrosine kinases that dictate cell fate. |
| 536 | _ | _ | |a 311 - Signalling pathways, cell and tumor biology (POF3-311) |0 G:(DE-HGF)POF3-311 |c POF3-311 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Carrier Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Tumor Suppressor Protein p53 |2 NLM Chemicals |
| 650 | _ | 7 | |a HIPK2 protein, human |0 EC 2.7.1.- |2 NLM Chemicals |
| 650 | _ | 7 | |a Proto-Oncogene Proteins c-abl |0 EC 2.7.10.2 |2 NLM Chemicals |
| 650 | _ | 7 | |a Protein-Serine-Threonine Kinases |0 EC 2.7.11.1 |2 NLM Chemicals |
| 700 | 1 | _ | |a Adler, Julia |b 1 |
| 700 | 1 | _ | |a Porat, Ziv |b 2 |
| 700 | 1 | _ | |a Polonio-Vallon, Tilman |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Hofmann, Thomas |0 P:(DE-He78)99ae95278bd95e30462a4fb2d12026c6 |b 4 |u dkfz |
| 700 | 1 | _ | |a Shaul, Yosef |b 5 |
| 773 | _ | _ | |a 10.1074/jbc.M114.628982 |g Vol. 290, no. 27, p. 16478 - 16488 |0 PERI:(DE-600)1474604-9 |n 27 |p 16478 - 16488 |t The journal of biological chemistry |v 290 |y 2015 |x 1083-351X |
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