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@ARTICLE{Rusek:127425,
      author       = {A. M. Rusek$^*$ and M. L. Abba$^*$ and A. Eljaszewicz and
                      M. Moniuszko and J. Niklinski and H. Allgayer$^*$},
      title        = {{M}icro{RNA} modulators of epigenetic regulation, the tumor
                      microenvironment and the immune system in lung cancer.319h},
      journal      = {Molecular cancer},
      volume       = {14},
      number       = {1},
      issn         = {1476-4598},
      address      = {London},
      publisher    = {Biomed Central},
      reportid     = {DKFZ-2017-03448},
      pages        = {34 -},
      year         = {2015},
      abstract     = {Cancer is an exceedingly complex disease that is
                      orchestrated and driven by a combination of multiple
                      aberrantly regulated processes. The nature and depth of
                      involvement of individual events vary between cancer types,
                      and in lung cancer, the deregulation of the epigenetic
                      machinery, the tumor microenvironment and the immune system
                      appear to be especially relevant. The contribution of
                      microRNAs to carcinogenesis and cancer progression is well
                      established with many reports and investigations describing
                      the involvement of microRNAs in lung cancer, however most of
                      these studies have concentrated on single microRNA-target
                      relations and have not adequately addressed the complexity
                      of their interactions. In this review, we focus, in part, on
                      the role of microRNAs in the epigenetic regulation of lung
                      cancer where they act as active molecules modulating enzymes
                      that take part in methylation-mediated silencing and
                      chromatin remodeling. Additionally, we highlight their
                      contribution in controlling and modulating the tumor
                      microenvironment and finally, we describe their role in the
                      critical alteration of essential molecules that influence
                      the immune system in lung cancer development and
                      progression.},
      keywords     = {MicroRNAs (NLM Chemicals)},
      cin          = {G360},
      ddc          = {610},
      cid          = {I:(DE-He78)G360-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25743773},
      pmc          = {pmc:PMC4333888},
      doi          = {10.1186/s12943-015-0302-8},
      url          = {https://inrepo02.dkfz.de/record/127425},
}