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@ARTICLE{Safi:127430,
      author       = {S. Safi and A. Benner$^*$ and J. Walloschek and M.
                      Renner$^*$ and J. op den Winkel and T. Muley and K. Storz
                      and H. Dienemann and H. Hoffmann and T. Schneider},
      title        = {{D}evelopment and validation of a risk score for predicting
                      death after pneumonectomy.},
      journal      = {PLoS one},
      volume       = {10},
      number       = {4},
      issn         = {1932-6203},
      address      = {Lawrence, Kan.},
      publisher    = {PLoS},
      reportid     = {DKFZ-2017-03453},
      pages        = {e0121295 -},
      year         = {2015},
      abstract     = {Pneumonectomy is associated with significant postoperative
                      mortality. This study was undertaken to develop and validate
                      a risk model of mortality following pneumonectomy. We
                      reviewed our prospective database and identified 774
                      pneumonectomies from a total of 7792 consecutive anatomical
                      lung resections in the years 2003 to 2010 (rate of
                      pneumonectomy: $9.9\%).$ Based on data from 542
                      pneumonectomies between 2003 and 2007 (i.e., the 'discovery
                      set'), a penalized multivariable logistic regression
                      analysis was performed to identify preoperative risk
                      factors. A risk model was developed and validated in an
                      independent data set of 232 pneumonectomies that were
                      performed between 2008 and 2010 (i.e., the 'validation
                      set'). Of the 542 patients in the discovery set (DS), 35
                      patients $(6.5\%)$ died after pneumonectomy during the same
                      admission. We developed a risk prediction model for
                      in-hospital mortality following pneumonectomy; that model
                      included age, current alcohol use, coronary artery disease,
                      preoperative leukocyte count and palliative indication as
                      possible risk factors. The risk model was subsequently
                      successfully validated in an independent data set (n = 232)
                      in which 18 patients $(7.8\%)$ died following pneumonectomy.
                      For the validation set, the sensitivity of the model was
                      $53.3\%$ (DS: $54.3\%),$ the specificity was $88.0\%$ (DS:
                      $87.4\%),$ the positive predictive value was $26.7\%$ (DS:
                      $22.9\%)$ and the negative predictive value was $95.8\%$
                      (DS: $96.5\%).$ The Brier score was 0.062 (DS: 0.054). The
                      prediction model is statistically valid and clinically
                      relevant.},
      cin          = {C060},
      ddc          = {500},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25856315},
      pmc          = {pmc:PMC4391778},
      doi          = {10.1371/journal.pone.0121295},
      url          = {https://inrepo02.dkfz.de/record/127430},
}