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000127444 0247_ $$2doi$$a10.1016/j.celrep.2015.08.024
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000127444 1001_ $$0P:(DE-HGF)0$$aSavant, Soniya$$b0$$eFirst author
000127444 245__ $$aThe Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells.
000127444 260__ $$aMaryland Heights, MO$$bCell Press$$c2015
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000127444 520__ $$aTie1 is a mechanistically poorly characterized endothelial cell (EC)-specific orphan receptor. Yet, Tie1 deletion is embryonic lethal and Tie1 has been implicated in critical vascular pathologies, including atherosclerosis and tumor angiogenesis. Here, we show that Tie1 does not function independently but exerts context-dependent effects on the related receptor Tie2. Tie1 was identified as an EC activation marker that is expressed during angiogenesis by a subset of angiogenic tip and remodeling stalk cells and downregulated in the adult quiescent vasculature. Functionally, Tie1 expression by angiogenic EC contributes to shaping the tip cell phenotype by negatively regulating Tie2 surface presentation. In contrast, Tie1 acts in remodeling stalk cells cooperatively to sustain Tie2 signaling. Collectively, our data support an interactive model of Tie1 and Tie2 function, in which dynamically regulated Tie1 versus Tie2 expression determines the net positive or negative effect of Tie1 on Tie2 signaling.
000127444 536__ $$0G:(DE-HGF)POF3-311$$a311 - Signalling pathways, cell and tumor biology (POF3-311)$$cPOF3-311$$fPOF III$$x0
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000127444 650_7 $$0EC 2.7.10.1$$2NLM Chemicals$$aReceptor, TIE-1
000127444 650_7 $$0EC 2.7.10.1$$2NLM Chemicals$$aReceptor, TIE-2
000127444 7001_ $$0P:(DE-He78)b8f19c256fc9d795781f1e0c6e7c5c6d$$aLa Porta, Silvia$$b1$$udkfz
000127444 7001_ $$0P:(DE-HGF)0$$aBudnik, Annika$$b2
000127444 7001_ $$0P:(DE-He78)6695811f3270b3dbe3d06842e2ca55cd$$aBusch, Katrin$$b3$$udkfz
000127444 7001_ $$0P:(DE-HGF)0$$aHu, Junhao$$b4
000127444 7001_ $$aTisch, Nathalie$$b5
000127444 7001_ $$0P:(DE-He78)9f5445b47d46f5f026560c307119a7da$$aKorn, Claudia$$b6$$udkfz
000127444 7001_ $$0P:(DE-HGF)0$$aValls, Aida Freire$$b7
000127444 7001_ $$0P:(DE-HGF)0$$aBenest, Andrew V$$b8
000127444 7001_ $$0P:(DE-He78)991812504757f41fde96045ecacfe0f5$$aTerhardt, Dorothee$$b9$$udkfz
000127444 7001_ $$aQu, Xianghu$$b10
000127444 7001_ $$aAdams, Ralf H$$b11
000127444 7001_ $$aBaldwin, H Scott$$b12
000127444 7001_ $$aRuiz de Almodóvar, Carmen$$b13
000127444 7001_ $$0P:(DE-He78)86fa3316b7be0d661065d02b3baec3d6$$aRodewald, Hans-Reimer$$b14$$udkfz
000127444 7001_ $$0P:(DE-He78)2e92d0ae281932fc7347d819fec36b0b$$aAugustin, Hellmut$$b15$$eLast author$$udkfz
000127444 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2015.08.024$$gVol. 12, no. 11, p. 1761 - 1773$$n11$$p1761 - 1773$$tCell reports$$v12$$x2211-1247$$y2015
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