%0 Journal Article
%A Savary, Camille C
%A Jiang, Xiaoqi
%A Aubry, Marc
%A Jossé, Rozenn
%A Kopp-Schneider, Annette
%A Hewitt, Philip
%A Guillouzo, André
%T Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period.
%J Toxicology in vitro
%V 30
%N 1 Pt A
%@ 0887-2333
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2017-03468
%P 27 - 35
%D 2015
%X Previous works have shown that differentiated human HepaRG cells can exhibit drug metabolism activities close to those of primary human hepatocytes for several weeks at confluence. The present study was designed to evaluate their long-term functional stability and their response to repeated daily drug treatments over a 14-day period, using a transcriptomic approach. Our data show that less than 1
%K Chromans (NLM Chemicals)
%K Hypoglycemic Agents (NLM Chemicals)
%K Hypolipidemic Agents (NLM Chemicals)
%K Peroxisome Proliferator-Activated Receptors (NLM Chemicals)
%K Thiazolidinediones (NLM Chemicals)
%K rosiglitazone (NLM Chemicals)
%K troglitazone (NLM Chemicals)
%K Fenofibrate (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:25572481
%R 10.1016/j.tiv.2014.12.019
%U https://inrepo02.dkfz.de/record/127445