TY  - JOUR
AU  - Savary, Camille C
AU  - Jiang, Xiaoqi
AU  - Aubry, Marc
AU  - Jossé, Rozenn
AU  - Kopp-Schneider, Annette
AU  - Hewitt, Philip
AU  - Guillouzo, André
TI  - Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period.
JO  - Toxicology in vitro
VL  - 30
IS  - 1 Pt A
SN  - 0887-2333
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2017-03468
SP  - 27 - 35
PY  - 2015
AB  - Previous works have shown that differentiated human HepaRG cells can exhibit drug metabolism activities close to those of primary human hepatocytes for several weeks at confluence. The present study was designed to evaluate their long-term functional stability and their response to repeated daily drug treatments over a 14-day period, using a transcriptomic approach. Our data show that less than 1
KW  - Chromans (NLM Chemicals)
KW  - Hypoglycemic Agents (NLM Chemicals)
KW  - Hypolipidemic Agents (NLM Chemicals)
KW  - Peroxisome Proliferator-Activated Receptors (NLM Chemicals)
KW  - Thiazolidinediones (NLM Chemicals)
KW  - rosiglitazone (NLM Chemicals)
KW  - troglitazone (NLM Chemicals)
KW  - Fenofibrate (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:25572481
DO  - DOI:10.1016/j.tiv.2014.12.019
UR  - https://inrepo02.dkfz.de/record/127445
ER  -