% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Savary:127445,
      author       = {C. C. Savary and X. Jiang$^*$ and M. Aubry and R. Jossé
                      and A. Kopp-Schneider$^*$ and P. Hewitt and A. Guillouzo},
      title        = {{T}ranscriptomic analysis of untreated and drug-treated
                      differentiated {H}epa{RG} cells over a 2-week period.},
      journal      = {Toxicology in vitro},
      volume       = {30},
      number       = {1 Pt A},
      issn         = {0887-2333},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2017-03468},
      pages        = {27 - 35},
      year         = {2015},
      abstract     = {Previous works have shown that differentiated human HepaRG
                      cells can exhibit drug metabolism activities close to those
                      of primary human hepatocytes for several weeks at
                      confluence. The present study was designed to evaluate their
                      long-term functional stability and their response to
                      repeated daily drug treatments over a 14-day period, using a
                      transcriptomic approach. Our data show that less than $1\%$
                      of the expressed genes were markedly deregulated over this
                      two weeks period and mainly included down-regulation of
                      genes related to the cell cycle and from 3 days,
                      overexpression of genes involved in xenobiotic and lipid
                      metabolism. After daily treatment with the three PPAR
                      agonists, fenofibrate, troglitazone and rosiglitazone
                      qualitative and/or quantitative changes in gene profiling
                      were observed depending on the compound and duration of
                      treatment. The highest increase in the number of deregulated
                      genes as a function of drug treatment was seen with
                      rosiglitazone. The most up-regulated genes common across the
                      three compounds were mainly related to lipid and xenobiotic
                      metabolisms. All the data support the conclusion that human
                      HepaRG cells have an exceptional functional stability at
                      confluence and that they are suitable for investigations on
                      chronic effects of drugs and other chemicals.},
      keywords     = {Chromans (NLM Chemicals) / Hypoglycemic Agents (NLM
                      Chemicals) / Hypolipidemic Agents (NLM Chemicals) /
                      Peroxisome Proliferator-Activated Receptors (NLM Chemicals)
                      / Thiazolidinediones (NLM Chemicals) / rosiglitazone (NLM
                      Chemicals) / troglitazone (NLM Chemicals) / Fenofibrate (NLM
                      Chemicals)},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25572481},
      doi          = {10.1016/j.tiv.2014.12.019},
      url          = {https://inrepo02.dkfz.de/record/127445},
}