%0 Journal Article
%A Schmidt, Martina
%A Chang-Claude, Jenny
%A Seibold, Petra
%A Vrieling, Alina
%A Heinz, Judith
%A Flesch-Janys, Dieter
%A Steindorf, Karen
%T Determinants of long-term fatigue in breast cancer survivors: results of a prospective patient cohort study.
%J Psycho-oncology
%V 24
%N 1
%@ 1057-9249
%C New York, NY [u.a.]
%I Wiley
%M DKFZ-2017-03485
%P 40 - 46
%D 2015
%X Fatigue is among the most distressing symptoms across the breast cancer continuum. However, little is known about the factors contributing to long-term persisting fatigue. Therefore, we explored determinants of long-term physical, affective, and cognitive fatigue in a prospective cohort of breast cancer patients.Breast cancer patients recruited in a population-based case-control study (MARIE study) provided comprehensive data on sociodemographics, lifestyle, and preexisting medical conditions. At follow-up (median 6.3 years post-diagnosis, MARIEplus), disease-free cancer survivors (N = 1928) reported current fatigue using a validated multidimensional questionnaire. Additionally, survivors retrospectively rated their fatigue levels before diagnosis, during the treatment phase, and 1 year post-surgery. Linear regression analyses were performed.As major determinants of long-term physical, affective, and cognitive fatigue, multiple regression analyses revealed preexisting psychological or depressive disorders, migraine, analgesic use, peripheral arterial obstructive disease (PAOD), and arthritis. A physically inactive lifestyle and obesity were associated with persisting physical fatigue. Aromatase inhibitors were also associated with long-term fatigue, especially cognitive fatigue. Chemotherapy and, to a lower extent, radiotherapy were major contributors to the development of fatigue during the treatment phase, yet were not associated with long-term fatigue.Although the development of fatigue in breast cancer patients seems largely impacted by cancer therapy, for the long-term persistence of fatigue, preexisting medical or psychological conditions related to depression or pain and lifestyle factors appear to be more relevant. Physicians, psycho-oncologists, and researchers may need to distinguish between acute fatigue during therapy and long-term persisting fatigue with regard to its pathophysiology and treatment.
%K Analgesics (NLM Chemicals)
%K Antineoplastic Agents (NLM Chemicals)
%K Aromatase Inhibitors (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:24839264
%R 10.1002/pon.3581
%U https://inrepo02.dkfz.de/record/127462