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000127462 0247_ $$2doi$$a10.1002/pon.3581
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000127462 0247_ $$2ISSN$$a1099-1611
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000127462 1001_ $$0P:(DE-He78)2def8f8594c8f797f5ed4398258c6cac$$aSchmidt, Martina$$b0$$eFirst author$$udkfz
000127462 245__ $$aDeterminants of long-term fatigue in breast cancer survivors: results of a prospective patient cohort study.
000127462 260__ $$aNew York, NY [u.a.]$$bWiley$$c2015
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000127462 520__ $$aFatigue is among the most distressing symptoms across the breast cancer continuum. However, little is known about the factors contributing to long-term persisting fatigue. Therefore, we explored determinants of long-term physical, affective, and cognitive fatigue in a prospective cohort of breast cancer patients.Breast cancer patients recruited in a population-based case-control study (MARIE study) provided comprehensive data on sociodemographics, lifestyle, and preexisting medical conditions. At follow-up (median 6.3 years post-diagnosis, MARIEplus), disease-free cancer survivors (N = 1928) reported current fatigue using a validated multidimensional questionnaire. Additionally, survivors retrospectively rated their fatigue levels before diagnosis, during the treatment phase, and 1 year post-surgery. Linear regression analyses were performed.As major determinants of long-term physical, affective, and cognitive fatigue, multiple regression analyses revealed preexisting psychological or depressive disorders, migraine, analgesic use, peripheral arterial obstructive disease (PAOD), and arthritis. A physically inactive lifestyle and obesity were associated with persisting physical fatigue. Aromatase inhibitors were also associated with long-term fatigue, especially cognitive fatigue. Chemotherapy and, to a lower extent, radiotherapy were major contributors to the development of fatigue during the treatment phase, yet were not associated with long-term fatigue.Although the development of fatigue in breast cancer patients seems largely impacted by cancer therapy, for the long-term persistence of fatigue, preexisting medical or psychological conditions related to depression or pain and lifestyle factors appear to be more relevant. Physicians, psycho-oncologists, and researchers may need to distinguish between acute fatigue during therapy and long-term persisting fatigue with regard to its pathophysiology and treatment.
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000127462 650_7 $$2NLM Chemicals$$aAnalgesics
000127462 650_7 $$2NLM Chemicals$$aAntineoplastic Agents
000127462 650_7 $$2NLM Chemicals$$aAromatase Inhibitors
000127462 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b1$$udkfz
000127462 7001_ $$0P:(DE-He78)fd17a8dbf8d08ea5bb656dfef7398215$$aSeibold, Petra$$b2$$udkfz
000127462 7001_ $$0P:(DE-HGF)0$$aVrieling, Alina$$b3
000127462 7001_ $$aHeinz, Judith$$b4
000127462 7001_ $$aFlesch-Janys, Dieter$$b5
000127462 7001_ $$0P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aSteindorf, Karen$$b6$$eLast author$$udkfz
000127462 773__ $$0PERI:(DE-600)1495115-0$$a10.1002/pon.3581$$gVol. 24, no. 1, p. 40 - 46$$n1$$p40 - 46$$tPsycho-oncology$$v24$$x1057-9249$$y2015
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