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| 024 | 7 | _ | |a 10.1002/pon.3581 |2 doi |
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| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 150 |
| 100 | 1 | _ | |a Schmidt, Martina |0 P:(DE-He78)2def8f8594c8f797f5ed4398258c6cac |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Determinants of long-term fatigue in breast cancer survivors: results of a prospective patient cohort study. |
| 260 | _ | _ | |a New York, NY [u.a.] |c 2015 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Fatigue is among the most distressing symptoms across the breast cancer continuum. However, little is known about the factors contributing to long-term persisting fatigue. Therefore, we explored determinants of long-term physical, affective, and cognitive fatigue in a prospective cohort of breast cancer patients.Breast cancer patients recruited in a population-based case-control study (MARIE study) provided comprehensive data on sociodemographics, lifestyle, and preexisting medical conditions. At follow-up (median 6.3 years post-diagnosis, MARIEplus), disease-free cancer survivors (N = 1928) reported current fatigue using a validated multidimensional questionnaire. Additionally, survivors retrospectively rated their fatigue levels before diagnosis, during the treatment phase, and 1 year post-surgery. Linear regression analyses were performed.As major determinants of long-term physical, affective, and cognitive fatigue, multiple regression analyses revealed preexisting psychological or depressive disorders, migraine, analgesic use, peripheral arterial obstructive disease (PAOD), and arthritis. A physically inactive lifestyle and obesity were associated with persisting physical fatigue. Aromatase inhibitors were also associated with long-term fatigue, especially cognitive fatigue. Chemotherapy and, to a lower extent, radiotherapy were major contributors to the development of fatigue during the treatment phase, yet were not associated with long-term fatigue.Although the development of fatigue in breast cancer patients seems largely impacted by cancer therapy, for the long-term persistence of fatigue, preexisting medical or psychological conditions related to depression or pain and lifestyle factors appear to be more relevant. Physicians, psycho-oncologists, and researchers may need to distinguish between acute fatigue during therapy and long-term persisting fatigue with regard to its pathophysiology and treatment. |
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| 650 | _ | 7 | |a Analgesics |2 NLM Chemicals |
| 650 | _ | 7 | |a Antineoplastic Agents |2 NLM Chemicals |
| 650 | _ | 7 | |a Aromatase Inhibitors |2 NLM Chemicals |
| 700 | 1 | _ | |a Chang-Claude, Jenny |0 P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253 |b 1 |u dkfz |
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| 700 | 1 | _ | |a Vrieling, Alina |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Heinz, Judith |b 4 |
| 700 | 1 | _ | |a Flesch-Janys, Dieter |b 5 |
| 700 | 1 | _ | |a Steindorf, Karen |0 P:(DE-He78)a0c2037d9054be26907a05ae520d5756 |b 6 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1002/pon.3581 |g Vol. 24, no. 1, p. 40 - 46 |0 PERI:(DE-600)1495115-0 |n 1 |p 40 - 46 |t Psycho-oncology |v 24 |y 2015 |x 1057-9249 |
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