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@ARTICLE{Schmidt:127463,
      author       = {M. Schmidt$^*$ and J. Wiskemann$^*$ and P. Armbrust$^*$ and
                      A. Schneeweiss and C. M. Ulrich$^*$ and K. Steindorf$^*$},
      title        = {{E}ffects of resistance exercise on fatigue and quality of
                      life in breast cancer patients undergoing adjuvant
                      chemotherapy: {A} randomized controlled trial.},
      journal      = {International journal of cancer},
      volume       = {137},
      number       = {2},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2017-03486},
      pages        = {471 - 480},
      year         = {2015},
      abstract     = {Multiple exercise interventions have shown beneficial
                      effects on fatigue and quality of life (QoL) in cancer
                      patients, but various psychosocial interventions as well. It
                      is unclear to what extent the observed effects of exercise
                      interventions are based on physical adaptations or rather on
                      psychosocial factors associated with supervised, group-based
                      programs. It needs to be determined which aspects of
                      exercise programs are truly effective. Therefore, we aimed
                      to investigate whether resistance exercise during
                      chemotherapy provides benefits on fatigue and QoL beyond
                      potential psychosocial effects of group-based interventions.
                      One-hundred-one breast cancer patients starting chemotherapy
                      were randomly assigned to resistance exercise (EX) or a
                      relaxation control (RC) group. Both interventions were
                      supervised, group-based, 2/week over 12 weeks. The primary
                      endpoint fatigue was assessed with a 20-item
                      multidimensional questionnaire, QoL with the EORTC
                      QLQ-C30/BR23. Analyses of covariance for individual changes
                      from baseline to Week 13 were calculated. In RC, total and
                      physical fatigue worsened during chemotherapy, whereas EX
                      showed no such impairments (between-group p = 0.098 and
                      0.052 overall, and p = 0.038 and 0.034 among patients
                      without severe baseline depression). Differences regarding
                      affective or cognitive fatigue were not significant.
                      Benefits of EX were also seen to affect role and social
                      function. Effect sizes were between 0.43 and 0.48.
                      Explorative analyses indicated significant effect
                      modification by thyroxin use (p-interaction = 0.044). In
                      conclusion, resistance exercise appeared to mitigate
                      physical fatigue and maintain QoL during chemotherapy beyond
                      psychosocial effects inherent to supervised group-based
                      settings. Thus, resistance exercise could be an integral
                      part of supportive care for breast cancer patients
                      undergoing chemotherapy.},
      cin          = {G110 / G111},
      ddc          = {610},
      cid          = {I:(DE-He78)G110-20160331 / I:(DE-He78)G111-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25484317},
      doi          = {10.1002/ijc.29383},
      url          = {https://inrepo02.dkfz.de/record/127463},
}