%0 Journal Article
%A Schöttker, Ben
%A Zhang, Yan
%A Heiss, Jonathan
%A Butterbach, Katja
%A Jansen, Eugène H J M
%A Bewerunge-Hudler, Melanie
%A Saum, Kai-Uwe
%A Holleczek, Bernd
%A Brenner, Hermann
%T Discovery of a novel epigenetic cancer marker related to the oxidative status of human blood.
%J Genes, chromosomes & cancer
%V 54
%N 9
%@ 1045-2257
%C New York, NY
%I Wiley-Liss
%M DKFZ-2017-03498
%P 583 - 594
%D 2015
%X Long-lasting oxidative stress exposure may lead to relatively stable epigenetic modifications of the DNA in order to activate anti-oxidative defence mechanisms. Oxidative stress related DNA methylation may therefore be associated (causally or as a by-product) with cancer. We measured derivatives of reactive oxygen metabolites (D-ROM), total thiol levels (TTL) and DNA methylation with the Illumina Infinium 450K BeadChip in three samples of German individuals aged ≥50 years: n = 1,000 ESTHER study baseline participants (DNA methylation only), n = 99 ESTHER eight-year follow-up participants and n = 142 participants of the BLITZ study. The correlation coefficient of methylation at cg10342304 and D-ROM in the ESTHER 8-year follow-up sample (r = -0.427; P = 1 × 10(-5)) was replicated with a P-value indicating statistical significance after correction for multiple testing in the BLITZ sample (r = -0.192; P = 0.022). The association was robust to adjusting for potential confounders. In the ESTHER baseline sample, the hazard ratio for cancer development in 11 years of follow-up comparing bottom and top quartile of DNA methylation at cg10342304 was 1.86 (95
%K Biomarkers, Tumor (NLM Chemicals)
%K Reactive Oxygen Species (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:26173806
%R 10.1002/gcc.22271
%U https://inrepo02.dkfz.de/record/127475