TY  - JOUR
AU  - Schöttker, Ben
AU  - Zhang, Yan
AU  - Heiss, Jonathan
AU  - Butterbach, Katja
AU  - Jansen, Eugène H J M
AU  - Bewerunge-Hudler, Melanie
AU  - Saum, Kai-Uwe
AU  - Holleczek, Bernd
AU  - Brenner, Hermann
TI  - Discovery of a novel epigenetic cancer marker related to the oxidative status of human blood.
JO  - Genes, chromosomes & cancer
VL  - 54
IS  - 9
SN  - 1045-2257
CY  - New York, NY
PB  - Wiley-Liss
M1  - DKFZ-2017-03498
SP  - 583 - 594
PY  - 2015
AB  - Long-lasting oxidative stress exposure may lead to relatively stable epigenetic modifications of the DNA in order to activate anti-oxidative defence mechanisms. Oxidative stress related DNA methylation may therefore be associated (causally or as a by-product) with cancer. We measured derivatives of reactive oxygen metabolites (D-ROM), total thiol levels (TTL) and DNA methylation with the Illumina Infinium 450K BeadChip in three samples of German individuals aged ≥50 years: n = 1,000 ESTHER study baseline participants (DNA methylation only), n = 99 ESTHER eight-year follow-up participants and n = 142 participants of the BLITZ study. The correlation coefficient of methylation at cg10342304 and D-ROM in the ESTHER 8-year follow-up sample (r = -0.427; P = 1 × 10(-5)) was replicated with a P-value indicating statistical significance after correction for multiple testing in the BLITZ sample (r = -0.192; P = 0.022). The association was robust to adjusting for potential confounders. In the ESTHER baseline sample, the hazard ratio for cancer development in 11 years of follow-up comparing bottom and top quartile of DNA methylation at cg10342304 was 1.86 (95
KW  - Biomarkers, Tumor (NLM Chemicals)
KW  - Reactive Oxygen Species (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26173806
DO  - DOI:10.1002/gcc.22271
UR  - https://inrepo02.dkfz.de/record/127475
ER  -