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| 001 | 127475 | ||
| 005 | 20240228140930.0 | ||
| 024 | 7 | _ | |a 10.1002/gcc.22271 |2 doi |
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| 024 | 7 | _ | |a 1045-2257 |2 ISSN |
| 024 | 7 | _ | |a 1098-2264 |2 ISSN |
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| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Schöttker, Ben |0 P:(DE-He78)c67a12496b8aac150c0eef888d808d46 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Discovery of a novel epigenetic cancer marker related to the oxidative status of human blood. |
| 260 | _ | _ | |a New York, NY |c 2015 |b Wiley-Liss |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521712215_15724 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Long-lasting oxidative stress exposure may lead to relatively stable epigenetic modifications of the DNA in order to activate anti-oxidative defence mechanisms. Oxidative stress related DNA methylation may therefore be associated (causally or as a by-product) with cancer. We measured derivatives of reactive oxygen metabolites (D-ROM), total thiol levels (TTL) and DNA methylation with the Illumina Infinium 450K BeadChip in three samples of German individuals aged ≥50 years: n = 1,000 ESTHER study baseline participants (DNA methylation only), n = 99 ESTHER eight-year follow-up participants and n = 142 participants of the BLITZ study. The correlation coefficient of methylation at cg10342304 and D-ROM in the ESTHER 8-year follow-up sample (r = -0.427; P = 1 × 10(-5)) was replicated with a P-value indicating statistical significance after correction for multiple testing in the BLITZ sample (r = -0.192; P = 0.022). The association was robust to adjusting for potential confounders. In the ESTHER baseline sample, the hazard ratio for cancer development in 11 years of follow-up comparing bottom and top quartile of DNA methylation at cg10342304 was 1.86 (95%-confidence-interval 1.01-3.43). In summary, this first epigenome-wide screening and replication study with oxidative status markers observed a negative correlation of D-ROM levels and DNA methylation at cg10342304 in two independent cohorts. This CpG site is located in the body region of the nucleoredoxin gene. The nucleoredoxin protein is a redox-dependent inhibitor of the Wnt/ß-catenin signaling pathway, a well-characterized cancer pathway. If the observed CpG-cancer association can be successfully replicated by other studies, this epigenetic marker could be an interesting biomarker of cancer risk. |
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| 650 | _ | 7 | |a Biomarkers, Tumor |2 NLM Chemicals |
| 650 | _ | 7 | |a Reactive Oxygen Species |2 NLM Chemicals |
| 700 | 1 | _ | |a Zhang, Yan |0 P:(DE-He78)6a8f87626cb610618a60d742677284cd |b 1 |u dkfz |
| 700 | 1 | _ | |a Heiss, Jonathan |0 P:(DE-He78)d3e4e449f4ed4d38e6ec44362e89dbc8 |b 2 |u dkfz |
| 700 | 1 | _ | |a Butterbach, Katja |0 P:(DE-He78)7ca7eafba864e5c3ebb7598149380452 |b 3 |u dkfz |
| 700 | 1 | _ | |a Jansen, Eugène H J M |b 4 |
| 700 | 1 | _ | |a Bewerunge-Hudler, Melanie |0 P:(DE-He78)7999346780553d7fab7ba69d5afdfa71 |b 5 |u dkfz |
| 700 | 1 | _ | |a Saum, Kai-Uwe |0 P:(DE-He78)97343bbd9545a4b87574e74329dabfd1 |b 6 |u dkfz |
| 700 | 1 | _ | |a Holleczek, Bernd |b 7 |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 8 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1002/gcc.22271 |g Vol. 54, no. 9, p. 583 - 594 |0 PERI:(DE-600)1492641-6 |n 9 |p 583 - 594 |t Genes, chromosomes & cancer |v 54 |y 2015 |x 1045-2257 |
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