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| 001 | 127604 | ||
| 005 | 20240228135030.0 | ||
| 024 | 7 | _ | |a 10.1186/1748-717X-9-113 |2 doi |
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| 041 | _ | _ | |a eng |
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| 100 | 1 | _ | |a Koerber, Stefan Alexander |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Efficacy and toxicity of chemoradiation in patients with anal cancer--a retrospective analysis. |
| 260 | _ | _ | |a London |c 2014 |b BioMed Central |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Concurrent chemotherapy and radiation therapy is the preferred standard of care for patients with anal cancer. Several studies have suggested a benefit of intensity-modulated radiation therapy (IMRT) compared with 3D-conformal radiation (3D-CRT) regarding acute toxicity. This study evaluates outcome and toxicity of patients undergoing IMRT/Tomotherapy or 3D-CRT at our institution.A cohort of 105 anal cancer patients was treated with chemoradiation or radiation alone (16.2%) between January 2000 and December 2011. 37 patients received 3D-CRT while 68 patients were treated with IMRT. Follow-up exams were performed every 3 to 6 months for a minimum of 3 years and then annually.Median follow-up was 41.4 months (2.8 - 158.4). Overall survival (OS), Progression-free survival (PFS) and local control (LC) at 3 years was 70.3%, 66.5%, 78.3% in the 3D-CRT group and 82.9%, 66.5%, 75.3% in the IMRT group without statistically significant difference. 3-year Colostomy-free survival (CFS) was 85.7% in the IMRT/Tomotherapy group and 91.8% in the 3D-CRT group (p = 0.48). No grade 4 toxicity was found in both groups. Severe (G2/3) acute skin toxicity (94.6% vs. 63.2%; p < 0.001) and acute gastrointestinal toxicity rate (67.6% vs. 47.1%; p = 0.03) was significantly higher with 3D-CRT compared to IMRT/Tomotherapy.The use of IMRT can reduce acute severe side effects of the skin and gastrointestinal tract but did not demonstrate improved results regarding OS, PFS, LC and CFS. |
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| 700 | 1 | _ | |a Slynko, Alla |0 P:(DE-He78)4169c43af2de6fae487c89fc2e7cfaa8 |b 1 |u dkfz |
| 700 | 1 | _ | |a Haefner, Matthias F |b 2 |
| 700 | 1 | _ | |a Krug, David |b 3 |
| 700 | 1 | _ | |a Schoneweg, Clara |b 4 |
| 700 | 1 | _ | |a Kessel, Kerstin |b 5 |
| 700 | 1 | _ | |a Kopp-Schneider, Annette |0 P:(DE-He78)bb6a7a70f976eb8df1769944bf913596 |b 6 |u dkfz |
| 700 | 1 | _ | |a Herfarth, Klaus |b 7 |
| 700 | 1 | _ | |a Debus, Juergen |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Sterzing, Florian |0 P:(DE-He78)75d45845a04db67c5a88db1086046ef1 |b 9 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1186/1748-717X-9-113 |g Vol. 9, no. 1, p. 113 - |0 PERI:(DE-600)2224965-5 |n 1 |p 113 |t Radiation oncology |v 9 |y 2014 |x 1748-717X |
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