%0 Journal Article
%A Koerber, Stefan Alexander
%A Schoneweg, Clara
%A Slynko, Alla
%A Krug, David
%A Haefner, Matthias F
%A Herfarth, Klaus
%A Debus, Juergen
%A Sterzing, Florian
%A von Knebel Doeberitz, Magnus
%A Prigge, Elena-Sophie
%A Reuschenbach, Miriam
%T Influence of human papillomavirus and p16(INK4a) on treatment outcome of patients with anal cancer.
%J Radiotherapy and oncology
%V 113
%N 3
%@ 0167-8140
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2017-03628
%P 331 - 336
%D 2014
%X The purpose of this study was to evaluate HPV-DNA and p16(INK4a) (p16) expression as prognostic markers for outcome in patients with anal cancer.From January 2000 to December 2011 a cohort of 105 anal cancer patients was treated with definitive chemoradiation at our institution. Tumor biopsies from 90 patients were analyzed for HPV-DNA by polymerase chain reaction and for p16 expression by immunohistochemistry.Median follow-up was 48.6months (range 2.8-169.1months). HPV-DNA or p16-expression was found in 75 anal cancers each (83.3
%K Biomarkers, Tumor (NLM Chemicals)
%K Cyclin-Dependent Kinase Inhibitor p16 (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:25465729
%R 10.1016/j.radonc.2014.11.013
%U https://inrepo02.dkfz.de/record/127605