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000127605 0247_ $$2doi$$a10.1016/j.radonc.2014.11.013
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000127605 1001_ $$0P:(DE-HGF)0$$aKoerber, Stefan Alexander$$b0$$eFirst author
000127605 245__ $$aInfluence of human papillomavirus and p16(INK4a) on treatment outcome of patients with anal cancer.
000127605 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2014
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000127605 520__ $$aThe purpose of this study was to evaluate HPV-DNA and p16(INK4a) (p16) expression as prognostic markers for outcome in patients with anal cancer.From January 2000 to December 2011 a cohort of 105 anal cancer patients was treated with definitive chemoradiation at our institution. Tumor biopsies from 90 patients were analyzed for HPV-DNA by polymerase chain reaction and for p16 expression by immunohistochemistry.Median follow-up was 48.6months (range 2.8-169.1months). HPV-DNA or p16-expression was found in 75 anal cancers each (83.3%), concordance was detectable in 70 tumors (77.8%). Significantly improved overall survival (OS) [77.1% vs. 51.4%, p=0.005], progression-free survival (PFS) [64.0% vs. 35.0%, p<0.001] and improved local control [81.0% vs. 55.9%, p=0.023] was found for concomitant HPV- and p16-positive anal carcinomas (cHPPAC) in univariate analysis. Multivariate analysis showed better OS [p=0.015] and PFS [p=0.002] for cHPPAC.The combination of HPV-DNA and p16 can be used as an independent prognostic parameter in anal cancer patients.
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000127605 650_7 $$2NLM Chemicals$$aBiomarkers, Tumor
000127605 650_7 $$2NLM Chemicals$$aCyclin-Dependent Kinase Inhibitor p16
000127605 7001_ $$0P:(DE-HGF)0$$aSchoneweg, Clara$$b1
000127605 7001_ $$0P:(DE-He78)4169c43af2de6fae487c89fc2e7cfaa8$$aSlynko, Alla$$b2
000127605 7001_ $$0P:(DE-HGF)0$$aKrug, David$$b3
000127605 7001_ $$0P:(DE-HGF)0$$aHaefner, Matthias F$$b4
000127605 7001_ $$0P:(DE-HGF)0$$aHerfarth, Klaus$$b5
000127605 7001_ $$0P:(DE-HGF)0$$aDebus, Juergen$$b6
000127605 7001_ $$0P:(DE-He78)75d45845a04db67c5a88db1086046ef1$$aSterzing, Florian$$b7
000127605 7001_ $$0P:(DE-He78)11747cd1dc061b9333c0e3a3ff31bf2f$$avon Knebel Doeberitz, Magnus$$b8
000127605 7001_ $$0P:(DE-He78)83e1d0ede46be662d4a75f18e2dc7eec$$aPrigge, Elena-Sophie$$b9
000127605 7001_ $$0P:(DE-He78)143aa3fb27761522adf5909af9a5fd26$$aReuschenbach, Miriam$$b10$$eLast author
000127605 773__ $$0PERI:(DE-600)1500707-8$$a10.1016/j.radonc.2014.11.013$$gVol. 113, no. 3, p. 331 - 336$$n3$$p331 - 336$$tRadiotherapy and oncology$$v113$$x0167-8140$$y2014
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