TY  - JOUR
AU  - Koerber, Stefan Alexander
AU  - Schoneweg, Clara
AU  - Slynko, Alla
AU  - Krug, David
AU  - Haefner, Matthias F
AU  - Herfarth, Klaus
AU  - Debus, Juergen
AU  - Sterzing, Florian
AU  - von Knebel Doeberitz, Magnus
AU  - Prigge, Elena-Sophie
AU  - Reuschenbach, Miriam
TI  - Influence of human papillomavirus and p16(INK4a) on treatment outcome of patients with anal cancer.
JO  - Radiotherapy and oncology
VL  - 113
IS  - 3
SN  - 0167-8140
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2017-03628
SP  - 331 - 336
PY  - 2014
AB  - The purpose of this study was to evaluate HPV-DNA and p16(INK4a) (p16) expression as prognostic markers for outcome in patients with anal cancer.From January 2000 to December 2011 a cohort of 105 anal cancer patients was treated with definitive chemoradiation at our institution. Tumor biopsies from 90 patients were analyzed for HPV-DNA by polymerase chain reaction and for p16 expression by immunohistochemistry.Median follow-up was 48.6months (range 2.8-169.1months). HPV-DNA or p16-expression was found in 75 anal cancers each (83.3
KW  - Biomarkers, Tumor (NLM Chemicals)
KW  - Cyclin-Dependent Kinase Inhibitor p16 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:25465729
DO  - DOI:10.1016/j.radonc.2014.11.013
UR  - https://inrepo02.dkfz.de/record/127605
ER  -