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| 001 | 127605 | ||
| 005 | 20240228135030.0 | ||
| 024 | 7 | _ | |a 10.1016/j.radonc.2014.11.013 |2 doi |
| 024 | 7 | _ | |a pmid:25465729 |2 pmid |
| 024 | 7 | _ | |a 0167-8140 |2 ISSN |
| 024 | 7 | _ | |a 1879-0887 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2017-03628 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Koerber, Stefan Alexander |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Influence of human papillomavirus and p16(INK4a) on treatment outcome of patients with anal cancer. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2014 |b Elsevier Science |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1522932009_31809 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The purpose of this study was to evaluate HPV-DNA and p16(INK4a) (p16) expression as prognostic markers for outcome in patients with anal cancer.From January 2000 to December 2011 a cohort of 105 anal cancer patients was treated with definitive chemoradiation at our institution. Tumor biopsies from 90 patients were analyzed for HPV-DNA by polymerase chain reaction and for p16 expression by immunohistochemistry.Median follow-up was 48.6months (range 2.8-169.1months). HPV-DNA or p16-expression was found in 75 anal cancers each (83.3%), concordance was detectable in 70 tumors (77.8%). Significantly improved overall survival (OS) [77.1% vs. 51.4%, p=0.005], progression-free survival (PFS) [64.0% vs. 35.0%, p<0.001] and improved local control [81.0% vs. 55.9%, p=0.023] was found for concomitant HPV- and p16-positive anal carcinomas (cHPPAC) in univariate analysis. Multivariate analysis showed better OS [p=0.015] and PFS [p=0.002] for cHPPAC.The combination of HPV-DNA and p16 can be used as an independent prognostic parameter in anal cancer patients. |
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| 650 | _ | 7 | |a Biomarkers, Tumor |2 NLM Chemicals |
| 650 | _ | 7 | |a Cyclin-Dependent Kinase Inhibitor p16 |2 NLM Chemicals |
| 700 | 1 | _ | |a Schoneweg, Clara |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Slynko, Alla |0 P:(DE-He78)4169c43af2de6fae487c89fc2e7cfaa8 |b 2 |
| 700 | 1 | _ | |a Krug, David |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Haefner, Matthias F |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Herfarth, Klaus |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Debus, Juergen |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Sterzing, Florian |0 P:(DE-He78)75d45845a04db67c5a88db1086046ef1 |b 7 |
| 700 | 1 | _ | |a von Knebel Doeberitz, Magnus |0 P:(DE-He78)11747cd1dc061b9333c0e3a3ff31bf2f |b 8 |
| 700 | 1 | _ | |a Prigge, Elena-Sophie |0 P:(DE-He78)83e1d0ede46be662d4a75f18e2dc7eec |b 9 |
| 700 | 1 | _ | |a Reuschenbach, Miriam |0 P:(DE-He78)143aa3fb27761522adf5909af9a5fd26 |b 10 |e Last author |
| 773 | _ | _ | |a 10.1016/j.radonc.2014.11.013 |g Vol. 113, no. 3, p. 331 - 336 |0 PERI:(DE-600)1500707-8 |n 3 |p 331 - 336 |t Radiotherapy and oncology |v 113 |y 2014 |x 0167-8140 |
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