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000127669 1001_ $$0P:(DE-He78)a229f7724466e7efadf4a1ace1ff8af3$$aUtikal, Jochen$$b0$$eFirst author$$udkfz
000127669 245__ $$aFunction and significance of MicroRNAs in benign and malignant human stem cells.
000127669 260__ $$aLondon$$bAcademic Press$$c2015
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000127669 520__ $$aMicroRNAs now not only represent a significant mechanism for post-transcriptional gene regulation, but have come to be appreciated as molecules with far reaching tentacles affecting diverse processes and pathologies by modulating amongst others, cellular gene expression, epigentic mechanisms, complex signaling cascades, cell-cell communication, the immune system and microenvironmental interactions between several cell types, tissues and organ systems. In this review, we systematically reflect on the impact of miRNAs on all types of benign and malignant human stem cells, looking at the roles they play in maintaining or changing the stem cell state, and review how aberrations of their expression and function within diverse types of stem cells orchestrate carcinogenesis and metastasis. As a conclusion, we consider it striking to see how similar some miR-driven mechanisms are between different types of stem cells and cancer cells, and how this might support hypotheses of miR-driven embryologic pathway reactivation in metastasis or propose putative functions of miRs in important novel cross-topic fields such as obesity and cancer.
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000127669 7001_ $$aAbba, Mohammed$$b1
000127669 7001_ $$0P:(DE-He78)5f0b1c9863f44d0695555ee3c22b9758$$aNovak, Daniel$$b2$$udkfz
000127669 7001_ $$aMoniuszko, Marcin$$b3
000127669 7001_ $$0P:(DE-He78)69067807288b48415ceb4abc43b9ad54$$aAllgayer, Heike$$b4$$eLast author$$udkfz
000127669 773__ $$0PERI:(DE-600)1471735-9$$a10.1016/j.semcancer.2015.07.001$$gVol. 35, p. 200 - 211$$p200 - 211$$tSeminars in cancer biology$$v35$$x1044-579X$$y2015
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