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@ARTICLE{Utikal:127669,
      author       = {J. Utikal$^*$ and M. Abba and D. Novak$^*$ and M. Moniuszko
                      and H. Allgayer$^*$},
      title        = {{F}unction and significance of {M}icro{RNA}s in benign and
                      malignant human stem cells.},
      journal      = {Seminars in cancer biology},
      volume       = {35},
      issn         = {1044-579X},
      address      = {London},
      publisher    = {Academic Press},
      reportid     = {DKFZ-2017-03692},
      pages        = {200 - 211},
      year         = {2015},
      abstract     = {MicroRNAs now not only represent a significant mechanism
                      for post-transcriptional gene regulation, but have come to
                      be appreciated as molecules with far reaching tentacles
                      affecting diverse processes and pathologies by modulating
                      amongst others, cellular gene expression, epigentic
                      mechanisms, complex signaling cascades, cell-cell
                      communication, the immune system and microenvironmental
                      interactions between several cell types, tissues and organ
                      systems. In this review, we systematically reflect on the
                      impact of miRNAs on all types of benign and malignant human
                      stem cells, looking at the roles they play in maintaining or
                      changing the stem cell state, and review how aberrations of
                      their expression and function within diverse types of stem
                      cells orchestrate carcinogenesis and metastasis. As a
                      conclusion, we consider it striking to see how similar some
                      miR-driven mechanisms are between different types of stem
                      cells and cancer cells, and how this might support
                      hypotheses of miR-driven embryologic pathway reactivation in
                      metastasis or propose putative functions of miRs in
                      important novel cross-topic fields such as obesity and
                      cancer.},
      keywords     = {MicroRNAs (NLM Chemicals)},
      cin          = {G300 / G360},
      ddc          = {570},
      cid          = {I:(DE-He78)G300-20160331 / I:(DE-He78)G360-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26192966},
      doi          = {10.1016/j.semcancer.2015.07.001},
      url          = {https://inrepo02.dkfz.de/record/127669},
}