guest ::
| Home > Publications database > Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. > print |
| Home > Publications database > Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. > print |
| 001 | 127743 | ||
| 005 | 20240228140947.0 | ||
| 024 | 7 | _ | |a 10.1038/nature14131 |2 doi |
| 024 | 7 | _ | |a pmid:25707806 |2 pmid |
| 024 | 7 | _ | |a 0028-0836 |2 ISSN |
| 024 | 7 | _ | |a 1476-4687 |2 ISSN |
| 024 | 7 | _ | |a altmetric:3709136 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-03766 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 070 |
| 100 | 1 | _ | |a Walter, Dagmar |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. |
| 260 | _ | _ | |a London [u.a.] |c 2015 |b Nature Publ. Group |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1508331520_31106 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Haematopoietic stem cells (HSCs) are responsible for the lifelong production of blood cells. The accumulation of DNA damage in HSCs is a hallmark of ageing and is probably a major contributing factor in age-related tissue degeneration and malignant transformation. A number of accelerated ageing syndromes are associated with defective DNA repair and genomic instability, including the most common inherited bone marrow failure syndrome, Fanconi anaemia. However, the physiological source of DNA damage in HSCs from both normal and diseased individuals remains unclear. Here we show in mice that DNA damage is a direct consequence of inducing HSCs to exit their homeostatic quiescent state in response to conditions that model physiological stress, such as infection or chronic blood loss. Repeated activation of HSCs out of their dormant state provoked the attrition of normal HSCs and, in the case of mice with a non-functional Fanconi anaemia DNA repair pathway, led to a complete collapse of the haematopoietic system, which phenocopied the highly penetrant bone marrow failure seen in Fanconi anaemia patients. Our findings establish a novel link between physiological stress and DNA damage in normal HSCs and provide a mechanistic explanation for the universal accumulation of DNA damage in HSCs during ageing and the accelerated failure of the haematopoietic system in Fanconi anaemia patients. |
| 536 | _ | _ | |a 311 - Signalling pathways, cell and tumor biology (POF3-311) |0 G:(DE-HGF)POF3-311 |c POF3-311 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Reactive Oxygen Species |2 NLM Chemicals |
| 700 | 1 | _ | |a Lier, Amelie |0 P:(DE-He78)f2177f299ad93efd161811e331914297 |b 1 |u dkfz |
| 700 | 1 | _ | |a Geiselhart, Anja |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Thalheimer, Frederic B |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Huntscha, Sina |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Sobotta, Mirko C |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Moehrle, Bettina |b 6 |
| 700 | 1 | _ | |a Brocks, David |0 P:(DE-He78)3860e24c3868c15255c3383a58e8d5b8 |b 7 |u dkfz |
| 700 | 1 | _ | |a Bayindir, Irem |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Kaschutnig, Paul Emanuel |0 P:(DE-He78)6d878e5c991d4938a3ee892d27309a38 |b 9 |u dkfz |
| 700 | 1 | _ | |a Muedder, Katja |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Klein, Corinna |0 P:(DE-He78)0812f68beb25392984d3abbe3c58b6d2 |b 11 |u dkfz |
| 700 | 1 | _ | |a Jauch, Anna |b 12 |
| 700 | 1 | _ | |a Schroeder, Timm |b 13 |
| 700 | 1 | _ | |a Geiger, Hartmut |b 14 |
| 700 | 1 | _ | |a Dick, Tobias |0 P:(DE-He78)7f55a0ed8b021080de00960cc73768fb |b 15 |u dkfz |
| 700 | 1 | _ | |a Holland-Letz, Tim |0 P:(DE-He78)457c042884c901eb0a02c18bb1d30103 |b 16 |u dkfz |
| 700 | 1 | _ | |a Schmezer, Peter |0 P:(DE-He78)141ce740f5d881812d2675147b72ecaf |b 17 |u dkfz |
| 700 | 1 | _ | |a Lane, Steven W |0 P:(DE-HGF)0 |b 18 |
| 700 | 1 | _ | |a Rieger, Michael A |b 19 |
| 700 | 1 | _ | |a Essers, Marieke |0 P:(DE-He78)ba3fae49054b6bfaaa289b05ecd936d6 |b 20 |u dkfz |
| 700 | 1 | _ | |a Williams, David A |b 21 |
| 700 | 1 | _ | |a Trumpp, Andreas |0 P:(DE-He78)732f4fbcddb0042251aa759a2e74d3b2 |b 22 |u dkfz |
| 700 | 1 | _ | |a Milsom, Michael |0 P:(DE-He78)7b613cadb8c16ce178713e15b85d982c |b 23 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1038/nature14131 |g Vol. 520, no. 7548, p. 549 - 552 |0 PERI:(DE-600)1413423-8 |n 7548 |p 549 - 552 |t Nature |v 520 |y 2015 |x 1476-4687 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:127743 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 0 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 1 |6 P:(DE-He78)f2177f299ad93efd161811e331914297 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 3 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 4 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 5 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 7 |6 P:(DE-He78)3860e24c3868c15255c3383a58e8d5b8 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 8 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 9 |6 P:(DE-He78)6d878e5c991d4938a3ee892d27309a38 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 10 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 11 |6 P:(DE-He78)0812f68beb25392984d3abbe3c58b6d2 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 15 |6 P:(DE-He78)7f55a0ed8b021080de00960cc73768fb |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 16 |6 P:(DE-He78)457c042884c901eb0a02c18bb1d30103 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 17 |6 P:(DE-He78)141ce740f5d881812d2675147b72ecaf |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 20 |6 P:(DE-He78)ba3fae49054b6bfaaa289b05ecd936d6 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 22 |6 P:(DE-He78)732f4fbcddb0042251aa759a2e74d3b2 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 23 |6 P:(DE-He78)7b613cadb8c16ce178713e15b85d982c |
| 913 | 1 | _ | |a DE-HGF |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-311 |2 G:(DE-HGF)POF3-300 |v Signalling pathways, cell and tumor biology |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |b Gesundheit |
| 914 | 1 | _ | |y 2015 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b NATURE : 2015 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 30 |0 StatID:(DE-HGF)9930 |2 StatID |b NATURE : 2015 |
| 920 | 1 | _ | |0 I:(DE-He78)A010-20160331 |k A010 |l Stammzellen und Krebs |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)A160-20160331 |k A160 |l Redoxregulation |x 1 |
| 920 | 1 | _ | |0 I:(DE-He78)A012-20160331 |k A012 |l Experimentelle Hämatologie |x 2 |
| 920 | 1 | _ | |0 I:(DE-He78)A011-20160331 |k A011 |l Stressinduzierte Aktivierung von hämatopoetischen Stammzellen |x 3 |
| 920 | 1 | _ | |0 I:(DE-He78)C060-20160331 |k C060 |l Biostatistik |x 4 |
| 920 | 1 | _ | |0 I:(DE-He78)C010-20160331 |k C010 |l Epigenomik und Krebsrisikofaktoren |x 5 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)A010-20160331 |
| 980 | _ | _ | |a I:(DE-He78)A160-20160331 |
| 980 | _ | _ | |a I:(DE-He78)A012-20160331 |
| 980 | _ | _ | |a I:(DE-He78)A011-20160331 |
| 980 | _ | _ | |a I:(DE-He78)C060-20160331 |
| 980 | _ | _ | |a I:(DE-He78)C010-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|