000127785 001__ 127785
000127785 005__ 20240228140949.0
000127785 0247_ $$2doi$$a10.1038/ncomms9904
000127785 0247_ $$2pmid$$apmid:26603103
000127785 0247_ $$2pmc$$apmc:PMC4674781
000127785 0247_ $$2altmetric$$aaltmetric:4811043
000127785 037__ $$aDKFZ-2017-03807
000127785 041__ $$aeng
000127785 082__ $$a500
000127785 1001_ $$aWickström, Malin$$b0
000127785 245__ $$aWnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance.
000127785 260__ $$aLondon$$bNature Publishing Group$$c2015
000127785 3367_ $$2DRIVER$$aarticle
000127785 3367_ $$2DataCite$$aOutput Types/Journal article
000127785 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1508923338_22424
000127785 3367_ $$2BibTeX$$aARTICLE
000127785 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000127785 3367_ $$00$$2EndNote$$aJournal Article
000127785 520__ $$aThe DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly overexpressed in cancers and is implicated in the development of chemoresistance. The use of drugs inhibiting MGMT has been hindered by their haematologic toxicity and inefficiency. As a different strategy to inhibit MGMT we investigated cellular regulators of MGMT expression in multiple cancers. Here we show a significant correlation between Wnt signalling and MGMT expression in cancers with different origin and confirm the findings by bioinformatic analysis and immunofluorescence. We demonstrate Wnt-dependent MGMT gene expression and cellular co-localization between active β-catenin and MGMT. Pharmacological or genetic inhibition of Wnt activity downregulates MGMT expression and restores chemosensitivity of DNA-alkylating drugs in mouse models. These findings have potential therapeutic implications for chemoresistant cancers, especially of brain tumours where the use of temozolomide is frequently used in treatment.
000127785 536__ $$0G:(DE-HGF)POF3-312$$a312 - Functional and structural genomics (POF3-312)$$cPOF3-312$$fPOF III$$x0
000127785 588__ $$aDataset connected to CrossRef, PubMed,
000127785 650_7 $$2NLM Chemicals$$a2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide
000127785 650_7 $$2NLM Chemicals$$aAntineoplastic Agents
000127785 650_7 $$2NLM Chemicals$$aBenzeneacetamides
000127785 650_7 $$2NLM Chemicals$$aG007-LK
000127785 650_7 $$2NLM Chemicals$$aHeterocyclic Compounds, 3-Ring
000127785 650_7 $$2NLM Chemicals$$aLGK974
000127785 650_7 $$2NLM Chemicals$$aPyrans
000127785 650_7 $$2NLM Chemicals$$aPyrazines
000127785 650_7 $$2NLM Chemicals$$aPyridines
000127785 650_7 $$2NLM Chemicals$$aSulfones
000127785 650_7 $$2NLM Chemicals$$aTriazoles
000127785 650_7 $$2NLM Chemicals$$aTumor Suppressor Proteins
000127785 650_7 $$2NLM Chemicals$$aWnt Proteins
000127785 650_7 $$2NLM Chemicals$$aXAV939
000127785 650_7 $$2NLM Chemicals$$abeta Catenin
000127785 650_7 $$00H43101T0J$$2NLM Chemicals$$airinotecan
000127785 650_7 $$05J49Q6B70F$$2NLM Chemicals$$aVincristine
000127785 650_7 $$062UXS86T64$$2NLM Chemicals$$asalinomycin
000127785 650_7 $$07GR28W0FJI$$2NLM Chemicals$$aDacarbazine
000127785 650_7 $$080168379AG$$2NLM Chemicals$$aDoxorubicin
000127785 650_7 $$0EC 2.1.1.-$$2NLM Chemicals$$aDNA Modification Methylases
000127785 650_7 $$0EC 2.1.1.63$$2NLM Chemicals$$aMGMT protein, human
000127785 650_7 $$0EC 5.3.1.9$$2NLM Chemicals$$aGlucose-6-Phosphate Isomerase
000127785 650_7 $$0EC 6.5.1.-$$2NLM Chemicals$$aDNA Repair Enzymes
000127785 650_7 $$0JCX84Q7J1L$$2NLM Chemicals$$aCelecoxib
000127785 650_7 $$0Q20Q21Q62J$$2NLM Chemicals$$aCisplatin
000127785 650_7 $$0XT3Z54Z28A$$2NLM Chemicals$$aCamptothecin
000127785 650_7 $$0YF1K15M17Y$$2NLM Chemicals$$atemozolomide
000127785 7001_ $$aDyberg, Cecilia$$b1
000127785 7001_ $$aMilosevic, Jelena$$b2
000127785 7001_ $$aEinvik, Christer$$b3
000127785 7001_ $$00000-0003-1525-1921$$aCalero, Raul$$b4
000127785 7001_ $$aSveinbjörnsson, Baldur$$b5
000127785 7001_ $$aSandén, Emma$$b6
000127785 7001_ $$00000-0003-4326-8149$$aDarabi, Anna$$b7
000127785 7001_ $$aSiesjö, Peter$$b8
000127785 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b9$$udkfz
000127785 7001_ $$aKogner, Per$$b10
000127785 7001_ $$aBaryawno, Ninib$$b11
000127785 7001_ $$aJohnsen, John Inge$$b12
000127785 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/ncomms9904$$gVol. 6, p. 8904 -$$p8904 -$$tNature Communications$$v6$$x2041-1723$$y2015
000127785 909CO $$ooai:inrepo02.dkfz.de:127785$$pVDB
000127785 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000127785 9131_ $$0G:(DE-HGF)POF3-312$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vFunctional and structural genomics$$x0
000127785 9141_ $$y2015
000127785 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT COMMUN : 2015
000127785 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000127785 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000127785 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000127785 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000127785 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000127785 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ
000127785 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000127785 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000127785 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000127785 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000127785 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences
000127785 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000127785 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences
000127785 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000127785 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000127785 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bNAT COMMUN : 2015
000127785 9201_ $$0I:(DE-He78)B062-20160331$$kB062$$lPädiatrische Neuroonkologie$$x0
000127785 980__ $$ajournal
000127785 980__ $$aVDB
000127785 980__ $$aI:(DE-He78)B062-20160331
000127785 980__ $$aUNRESTRICTED