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@ARTICLE{Woik:127808,
      author       = {N. Woik$^*$ and J. Kroll$^*$},
      title        = {{R}egulation of lung development and regeneration by the
                      vascular system.},
      journal      = {Cellular and molecular life sciences},
      volume       = {72},
      number       = {14},
      issn         = {1420-9071},
      address      = {Basel},
      publisher    = {Birkhäuser},
      reportid     = {DKFZ-2017-03830},
      pages        = {2709 - 2718},
      year         = {2015},
      abstract     = {Blood vessels have been described a long time ago as
                      passive circuits providing sufficient blood supply to ensure
                      proper distribution of oxygen and nutrition. Blood vessels
                      are mainly formed during embryonic development and in the
                      early postnatal period. In the adult, blood vessels are
                      quiescent, but can be activated and subsequently induced
                      under pathophysiological conditions, such as ischemia and
                      tumor growth. Surprisingly, recent data have suggested an
                      active function for blood vessels, named angiocrine
                      signaling, releasing trophogens which regulate organ
                      development and organ regeneration including in the
                      pancreas, lung, tumor cells, liver and bone. Lung
                      development is driven by hypoxia as well as an intense
                      endothelial-epithelial interaction, and important mechanisms
                      contributing to these processes have recently been
                      identified. This review aims to summarize recent
                      developments and concepts about embryonic pulmonary vascular
                      development and lung regeneration. We discuss
                      hypoxia-inducible factor HIF-2α and vascular endothelial
                      growth factor VEGF as important mediators in lung
                      development and focus on endothelial-epithelial interactions
                      and angiocrine signaling mechanisms.},
      keywords     = {Basic Helix-Loop-Helix Transcription Factors (NLM
                      Chemicals) / Vascular Endothelial Growth Factor A (NLM
                      Chemicals) / endothelial PAS domain-containing protein 1
                      (NLM Chemicals)},
      cin          = {A190},
      ddc          = {570},
      cid          = {I:(DE-He78)A190-20160331},
      pnm          = {321 - Basic Concepts (POF3-321)},
      pid          = {G:(DE-HGF)POF3-321},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25894695},
      doi          = {10.1007/s00018-015-1907-1},
      url          = {https://inrepo02.dkfz.de/record/127808},
}