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@ARTICLE{Wrage:127812,
      author       = {M. Wrage and W. Hagmann$^*$ and D. Kemming and F. G.
                      Uzunoglu and S. Riethdorf and K. Effenberger and M. Westphal
                      and K. Lamszus and S.-Z. Kim and N. Becker$^*$ and J. R.
                      Izbicki and J. Sandoval and M. Esteller and K. Pantel and A.
                      Risch$^*$ and H. Wikman},
      title        = {{I}dentification of {HERC}5 and its potential role in
                      {NSCLC} progression.},
      journal      = {International journal of cancer},
      volume       = {136},
      number       = {10},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2017-03834},
      pages        = {2264 - 2272},
      year         = {2015},
      abstract     = {For better lung cancer diagnosis and therapy, early
                      detection markers of tumor dissemination are urgently
                      needed, as most lung cancers do not show symptoms until
                      extensive metastasis formation has already taken place. Our
                      previous studies showed that in non-small cell lung cancer
                      (NSCLC) early tumor dissemination is associated with a loss
                      of chromosome 4q12-q32 and the presence of disseminated
                      tumor cells (DTC) in the bone marrow. In order to identify
                      the potential target gene in this region, a screen for
                      methylation-dependent expression was performed. Lung cancer
                      cell lines showing a loss of 4q as well as a normal
                      bronchial epithelial cell line as control were treated with
                      5-aza-2'-deoxycytidine (5-aza-CdR) followed by expression
                      profiling. Seven genes within the 4q target region, which
                      have been associated with a positive DTC status before were
                      found to be regulated by hypermethylation. QRT-PCR in an
                      independent sample set identified HERC5 as a potential
                      target gene. Quantitative methylation analysis of these lung
                      tissue samples revealed that HERC5 promoter hypermethylation
                      was significantly associated with positive DTC status (p =
                      0.020) and occurrence of brain metastases (p = 0.015). In
                      addition, hypermethylation of the HERC5 promoter in NSCLC
                      was identified as a predictor for poor survival for Stage I
                      adenocarcinoma patients (p = 0.022) and also for poor
                      overall survival in metastatic lung cancer patients (p =
                      0.028). In conclusion, HERC5 may function as a prognostic
                      marker and is associated with tumor dissemination in lung
                      cancer.},
      keywords     = {HERC5 protein, human (NLM Chemicals) / Intracellular
                      Signaling Peptides and Proteins (NLM Chemicals) / decitabine
                      (NLM Chemicals) / Azacitidine (NLM Chemicals)},
      cin          = {C060 / C010},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331 / I:(DE-He78)C010-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25353388},
      doi          = {10.1002/ijc.29298},
      url          = {https://inrepo02.dkfz.de/record/127812},
}