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| 001 | 127820 | ||
| 005 | 20240228140951.0 | ||
| 024 | 7 | _ | |a 10.1002/ijc.29205 |2 doi |
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| 024 | 7 | _ | |a 0020-7136 |2 ISSN |
| 024 | 7 | _ | |a 1097-0215 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2017-03842 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Yang, Rongxi |0 P:(DE-He78)dd35af1fb84ec0812fe4bdea97d2f291 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a DNA methylation array analyses identified breast cancer-associated HYAL2 methylation in peripheral blood. |
| 260 | _ | _ | |a Bognor Regis |c 2015 |b Wiley-Liss |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521793884_5360 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Breast cancer (BC) is the leading cause of cancer-related mortality in women worldwide. Changes in DNA methylation in peripheral blood could be associated with malignancy at early stage. However, the BC-associated DNA methylation signatures in peripheral blood were largely unknown. Here, we performed a genome-wide methylation screening and identified a BC-associated differentially methylated CpG site cg27091787 in the hyaluronoglucosaminidase 2 gene (HYAL2) (discovery round with 72 BC case and 24 controls: p = 2.61 × 10(-9) adjusted for cell-type proportions). The substantially decreased methylation of cg27091787 in BC cases was confirmed in two validation rounds (first validation round with 338 BC case and 507 controls: p < 0.0001; second validation round with 189 BC case and 189 controls: p < 0.0001). In addition to cg27091787, the decreased methylation of a 650-bp CpG island shore of HYAL2 was also associated with increased risk of BC. Moreover, the expression and methylation of HYAL2 were inversely correlated with a p-value of 0.006. To note, the BC-associated decreased HYAL2 methylation was replicated in the T-cell fraction (p = 0.034). The cg27091787 methylation level enabled a powerful discrimination of early-stage BC cases (stages 0 and I) from healthy controls [area under curve (AUC) = 0.89], and was robust for the detection of BC in younger women as well (age < 50, AUC = 0.87). Our study reveals a strong association between decreased HYAL2 methylation in peripheral blood and BC, and provides a promising blood-based marker for the detection of early BC. |
| 536 | _ | _ | |a 313 - Cancer risk factors and prevention (POF3-313) |0 G:(DE-HGF)POF3-313 |c POF3-313 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Biomarkers, Tumor |2 NLM Chemicals |
| 650 | _ | 7 | |a Cell Adhesion Molecules |2 NLM Chemicals |
| 650 | _ | 7 | |a GPI-Linked Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Hyal2 protein, human |0 EC 3.2.1.25 |2 NLM Chemicals |
| 650 | _ | 7 | |a Hyaluronoglucosaminidase |0 EC 3.2.1.35 |2 NLM Chemicals |
| 700 | 1 | _ | |a Pfütze, Katrin |0 P:(DE-He78)83906db1355a576371363a4b9f107d3d |b 1 |u dkfz |
| 700 | 1 | _ | |a Zucknick, Manuela |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Sutter, Christian |b 3 |
| 700 | 1 | _ | |a Wappenschmidt, Barbara |b 4 |
| 700 | 1 | _ | |a Marme, Frederik |b 5 |
| 700 | 1 | _ | |a Qu, Bin |b 6 |
| 700 | 1 | _ | |a Cuk, Katarina |0 P:(DE-He78)0a8ada1f5d2ea05fc3af10cd808bfa9a |b 7 |u dkfz |
| 700 | 1 | _ | |a Engel, Christoph |b 8 |
| 700 | 1 | _ | |a Schott, Sarah |b 9 |
| 700 | 1 | _ | |a Schneeweiss, Andreas |b 10 |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 11 |u dkfz |
| 700 | 1 | _ | |a Claus, Rainer |0 P:(DE-HGF)0 |b 12 |
| 700 | 1 | _ | |a Plass, Christoph |0 P:(DE-He78)4301875630bc997edf491c694ae1f8a9 |b 13 |u dkfz |
| 700 | 1 | _ | |a Bugert, Peter |b 14 |
| 700 | 1 | _ | |a Hoth, Markus |b 15 |
| 700 | 1 | _ | |a Sohn, Christof |b 16 |
| 700 | 1 | _ | |a Schmutzler, Rita |b 17 |
| 700 | 1 | _ | |a Bartram, Claus R |b 18 |
| 700 | 1 | _ | |a Burwinkel, Barbara |0 P:(DE-He78)15b7fd2bc02d5ef47a2fe2dd0140d2bf |b 19 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1002/ijc.29205 |g Vol. 136, no. 8, p. 1845 - 1855 |0 PERI:(DE-600)1474822-8 |n 8 |p 1845 - 1855 |t International journal of cancer |v 136 |y 2015 |x 0020-7136 |
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