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@ARTICLE{Zrnig:127881,
      author       = {I. Zörnig$^*$ and N. Halama$^*$ and J. Lorenzo Bermejo and
                      C. Ziegelmeier$^*$ and E. Dickes$^*$ and A. Migdoll$^*$ and
                      I. Kaiser$^*$ and T. Waterboer$^*$ and M. Pawlita$^*$ and N.
                      Grabe$^*$ and S. Ugurel and D. Schadendorf and C. Falk and
                      S. Eichmüller$^*$ and D. Jäger$^*$},
      title        = {{P}rognostic significance of spontaneous antibody responses
                      against tumor-associated antigens in malignant melanoma
                      patients.},
      journal      = {International journal of cancer},
      volume       = {136},
      number       = {1},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2017-03903},
      pages        = {138 - 151},
      year         = {2015},
      abstract     = {Distribution, patterns and prognostic impact of spontaneous
                      antibody responses against different tumor-associated
                      antigens (TAAs) in malignant melanoma patients are unknown
                      so far and were investigated in this study for the first
                      time in a large cohort at different stages of the disease,
                      identifying new prognostic biomarkers for malignant
                      melanoma. Serum samples from 365 melanoma patients (97 Stage
                      I melanoma patients, 87 Stage II, 92 Stage III and 89 Stage
                      IV) and 100 age and gender matched healthy control donors
                      were analyzed. Samples were drawn at the time of diagnosis
                      (Stages I-III) or at time of diagnosis of distant metastasis
                      (Stage IV). Applying a novel multiplex assay, humoral immune
                      responses against 29 TAAs were determined and the
                      association between response and patient survival was
                      investigated. Antibody responses were mainly found in
                      melanoma patients and all tested antigens elicited immune
                      responses in all disease stages. Antibody responses against
                      single antigens were either associated with poor prognosis
                      and/or shorter progression-free survival (PFS) or had no
                      influence. While in Stages I-III significant associations
                      were observed between an antibody response and overall
                      survival or PFS, among Stage IV patients, no significant
                      association was found. Multivariate analyses identified
                      specific humoral immune responses as prognostic factors
                      independently of age, chemotherapy and immunotherapy.
                      Antibody responses against specific TAA in Stage I-III
                      melanoma patients correlate with poor prognosis and/or
                      shorter PFS. These results may help to design clinical
                      studies in order to evaluate the potential of these
                      responses as prognostic serological biomarkers.},
      keywords     = {Antigens, Neoplasm (NLM Chemicals)},
      cin          = {D120 / D015 / F020 / G010 / G183},
      ddc          = {610},
      cid          = {I:(DE-He78)D120-20160331 / I:(DE-He78)D015-20160331 /
                      I:(DE-He78)F020-20160331 / I:(DE-He78)G010-20160331 /
                      I:(DE-He78)G183-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24839182},
      doi          = {10.1002/ijc.28980},
      url          = {https://inrepo02.dkfz.de/record/127881},
}