TY  - JOUR
AU  - Matsushita, Kunihiro
AU  - Ballew, Shoshana H
AU  - Astor, Brad C
AU  - Jong, Paul E de
AU  - Gansevoort, Ron T
AU  - Hemmelgarn, Brenda R
AU  - Levey, Andrew S
AU  - Levin, Adeera
AU  - Wen, Chi-Pang
AU  - Woodward, Mark
AU  - Coresh, Josef
AU  - Brenner, Hermann
AU  - Müller
AU  - Schöttker, Ben
TI  - Cohort profile: the chronic kidney disease prognosis consortium.
JO  - International journal of epidemiology
VL  - 42
IS  - 6
SN  - 1464-3685
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2017-03931
SP  - 1660 - 1668
PY  - 2013
AB  - The Chronic Kidney Disease Prognosis Consortium (CKD-PC) was established in 2009 to provide comprehensive evidence about the prognostic impact of two key kidney measures that are used to define and stage CKD, estimated glomerular filtration rate (eGFR) and albuminuria, on mortality and kidney outcomes. CKD-PC currently consists of 46 cohorts with data on these kidney measures and outcomes from >2 million participants spanning across 40 countries/regions all over the world. CKD-PC published four meta-analysis articles in 2010-11, providing key evidence for an international consensus on the definition and staging of CKD and an update for CKD clinical practice guidelines. The consortium continues to work on more detailed analysis (subgroups, different eGFR equations, other exposures and outcomes, and risk prediction). CKD-PC preferably collects individual participant data but also applies a novel distributed analysis model, in which each cohort runs statistical analysis locally and shares only analysed outputs for meta-analyses. This distributed model allows inclusion of cohorts which cannot share individual participant level data. According to agreement with cohorts, CKD-PC will not share data with third parties, but is open to including further eligible cohorts. Each cohort can opt in/out for each topic. CKD-PC has established a productive and effective collaboration, allowing flexible participation and complex meta-analyses for studying CKD.
LB  - PUB:(DE-HGF)16
C6  - pmid:23243116
DO  - DOI:10.1093/ije/dys173
UR  - https://inrepo02.dkfz.de/record/127909
ER  -