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@ARTICLE{Mack:127989,
      author       = {S. C. Mack and H. Witt$^*$ and R. M. Piro$^*$ and L. Gu and
                      S. Zuyderduyn and A. Stütz$^*$ and X. Wang and M. Gallo and
                      L. Garzia and K. Zayne and X. Zhang and V. Ramaswamy and N.
                      Jäger$^*$ and D. Jones$^*$ and M. Sill$^*$ and T. J. Pugh
                      and M. Ryzhova$^*$ and K. M. Wani and D. J. H. Shih and R.
                      Head and M. Remke and S. D. Bailey and T. Zichner$^*$ and C.
                      C. Faria and M. Barszczyk and S. Stark$^*$ and H.
                      Seker-Cin$^*$ and S. Hutter$^*$ and P. Johann$^*$ and S.
                      Bender$^*$ and V. Hovestadt$^*$ and T. Tzaridis$^*$ and A.
                      M. Dubuc and P. A. Northcott$^*$ and J. Peacock and K. C.
                      Bertrand and S. Agnihotri and F. M. G. Cavalli and I. Clarke
                      and K. Nethery-Brokx and C. L. Creasy and S. K. Verma and J.
                      Koster and X. Wu and Y. Yao and T. Milde$^*$ and P. Sin-Chan
                      and J. Zuccaro and L. Lau and S. Pereira and P.
                      Castelo-Branco and M. Hirst and M. A. Marra and S. S.
                      Roberts and D. Fults and L. Massimi and Y. J. Cho and T. Van
                      Meter and W. Grajkowska and B. Lach and A. E. Kulozik$^*$
                      and A. von Deimling$^*$ and O. Witt$^*$ and S. W. Scherer
                      and X. Fan and K. M. Muraszko and M. Kool$^*$ and S. L.
                      Pomeroy and N. Gupta and J. Phillips and A. Huang and U.
                      Tabori and C. Hawkins and D. Malkin and P. N. Kongkham and
                      W. A. Weiss and N. Jabado and J. T. Rutka and E. Bouffet and
                      J. O. Korbel and M. Lupien and K. D. Aldape and G. D. Bader
                      and R. Eils$^*$ and P. Lichter$^*$ and P. B. Dirks and S.
                      Pfister$^*$ and A. Korshunov$^*$ and M. D. Taylor},
      title        = {{E}pigenomic alterations define lethal {CIMP}-positive
                      ependymomas of infancy.},
      journal      = {Nature},
      volume       = {506},
      number       = {7489},
      issn         = {1476-4687},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2017-04011},
      pages        = {445 - 450},
      year         = {2014},
      abstract     = {Ependymomas are common childhood brain tumours that occur
                      throughout the nervous system, but are most common in the
                      paediatric hindbrain. Current standard therapy comprises
                      surgery and radiation, but not cytotoxic chemotherapy as it
                      does not further increase survival. Whole-genome and
                      whole-exome sequencing of 47 hindbrain ependymomas reveals
                      an extremely low mutation rate, and zero significant
                      recurrent somatic single nucleotide variants. Although
                      devoid of recurrent single nucleotide variants and focal
                      copy number aberrations, poor-prognosis hindbrain
                      ependymomas exhibit a CpG island methylator phenotype.
                      Transcriptional silencing driven by CpG methylation
                      converges exclusively on targets of the Polycomb repressive
                      complex 2 which represses expression of differentiation
                      genes through trimethylation of H3K27. CpG island methylator
                      phenotype-positive hindbrain ependymomas are responsive to
                      clinical drugs that target either DNA or H3K27 methylation
                      both in vitro and in vivo. We conclude that epigenetic
                      modifiers are the first rational therapeutic candidates for
                      this deadly malignancy, which is epigenetically deregulated
                      but genetically bland.},
      keywords     = {Histones (NLM Chemicals) / Polycomb Repressive Complex 2
                      (NLM Chemicals)},
      cin          = {B062 / B060 / B080 / C060 / G340 / G380 / L101},
      ddc          = {070},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)B060-20160331 /
                      I:(DE-He78)B080-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)G340-20160331 / I:(DE-He78)G380-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24553142},
      pmc          = {pmc:PMC4174313},
      doi          = {10.1038/nature13108},
      url          = {https://inrepo02.dkfz.de/record/127989},
}