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000128015 0247_ $$2doi$$a10.1016/j.celrep.2017.08.005
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000128015 1001_ $$0P:(DE-He78)10a9b063005cea37559ebbb0142d23d0$$aCosenza, Marco Raffaele$$b0$$eFirst author$$udkfz
000128015 245__ $$aAsymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer.
000128015 260__ $$aMaryland Heights, MO$$bCell Press$$c2017
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000128015 520__ $$aChromosomal instability is a hallmark of cancer and correlates with the presence of extra centrosomes, which originate from centriole overduplication. Overduplicated centrioles lead to the formation of centriole rosettes, which mature into supernumerary centrosomes in the subsequent cell cycle. While extra centrosomes promote chromosome missegregation by clustering into pseudo-bipolar spindles, the contribution of centriole rosettes to chromosome missegregation is unknown. We used multi-modal imaging of cells with conditional centriole overduplication to show that mitotic rosettes in bipolar spindles frequently harbor unequal centriole numbers, leading to biased chromosome capture that favors binding to the prominent pole. This results in chromosome missegregation and aneuploidy. Rosette mitoses lead to viable offspring and significantly contribute to progeny production. We further show that centrosome abnormalities in primary human malignancies frequently consist of centriole rosettes. As asymmetric centriole rosettes generate mitotic errors that can be propagated, rosette mitoses are sufficient to cause chromosome missegregation in cancer.
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000128015 7001_ $$0P:(DE-He78)72adf4fc245c4132ec2b75277f99573c$$aCazzola, Anna$$b1$$udkfz
000128015 7001_ $$0P:(DE-HGF)0$$aRossberg, Annik$$b2
000128015 7001_ $$aSchieber, Nicole L$$b3
000128015 7001_ $$0P:(DE-He78)063aa0f47328a6f24c7e0bcdfd258b74$$aKonotop, Gleb$$b4$$udkfz
000128015 7001_ $$0P:(DE-He78)51d9a72bd08e54c9ae15b6c76e7e29f5$$aBausch, Elena$$b5$$udkfz
000128015 7001_ $$0P:(DE-He78)4169c43af2de6fae487c89fc2e7cfaa8$$aSlynko, Alla$$b6$$udkfz
000128015 7001_ $$0P:(DE-He78)457c042884c901eb0a02c18bb1d30103$$aHolland-Letz, Tim$$b7$$udkfz
000128015 7001_ $$0P:(DE-He78)1cb537e833afd985097ccfaddffb2ef3$$aRaab, Marc-Steffen$$b8$$udkfz
000128015 7001_ $$0P:(DE-He78)fd92a33f8a02f962db52bf8daa1b1dbf$$aDubash, Taronish Dorab$$b9$$udkfz
000128015 7001_ $$0P:(DE-He78)157277fe62f07df1732f9d126a51d1b9$$aGlimm, Hanno$$b10$$udkfz
000128015 7001_ $$0P:(DE-HGF)0$$aPoppelreuther, Sven$$b11
000128015 7001_ $$aHerold-Mende, Christel$$b12
000128015 7001_ $$aSchwab, Yannick$$b13
000128015 7001_ $$0P:(DE-He78)493c5fbf69f1b20df6f048712f3ad4a0$$aKrämer, Alwin$$b14$$eLast author$$udkfz
000128015 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2017.08.005$$gVol. 20, no. 8, p. 1906 - 1920$$n8$$p1906 - 1920$$tCell reports$$v20$$x2211-1247$$y2017
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