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@ARTICLE{Cosenza:128015,
      author       = {M. R. Cosenza$^*$ and A. Cazzola$^*$ and A. Rossberg$^*$
                      and N. L. Schieber and G. Konotop$^*$ and E. Bausch$^*$ and
                      A. Slynko$^*$ and T. Holland-Letz$^*$ and M.-S. Raab$^*$ and
                      T. D. Dubash$^*$ and H. Glimm$^*$ and S. Poppelreuther$^*$
                      and C. Herold-Mende and Y. Schwab and A. Krämer$^*$},
      title        = {{A}symmetric {C}entriole {N}umbers at {S}pindle {P}oles
                      {C}ause {C}hromosome {M}issegregation in {C}ancer.},
      journal      = {Cell reports},
      volume       = {20},
      number       = {8},
      issn         = {2211-1247},
      address      = {Maryland Heights, MO},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2017-04037},
      pages        = {1906 - 1920},
      year         = {2017},
      abstract     = {Chromosomal instability is a hallmark of cancer and
                      correlates with the presence of extra centrosomes, which
                      originate from centriole overduplication. Overduplicated
                      centrioles lead to the formation of centriole rosettes,
                      which mature into supernumerary centrosomes in the
                      subsequent cell cycle. While extra centrosomes promote
                      chromosome missegregation by clustering into pseudo-bipolar
                      spindles, the contribution of centriole rosettes to
                      chromosome missegregation is unknown. We used multi-modal
                      imaging of cells with conditional centriole overduplication
                      to show that mitotic rosettes in bipolar spindles frequently
                      harbor unequal centriole numbers, leading to biased
                      chromosome capture that favors binding to the prominent
                      pole. This results in chromosome missegregation and
                      aneuploidy. Rosette mitoses lead to viable offspring and
                      significantly contribute to progeny production. We further
                      show that centrosome abnormalities in primary human
                      malignancies frequently consist of centriole rosettes.
                      As asymmetric centriole rosettes generate mitotic errors
                      that can be propagated, rosette mitoses are sufficient to
                      cause chromosome missegregation in cancer.},
      cin          = {G330 / C060 / G170 / G100},
      ddc          = {570},
      cid          = {I:(DE-He78)G330-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)G170-20160331 / I:(DE-He78)G100-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28834753},
      doi          = {10.1016/j.celrep.2017.08.005},
      url          = {https://inrepo02.dkfz.de/record/128015},
}