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@ARTICLE{Glck:128029,
      author       = {S. Glück and B. Guey and M. F. Gulen and K. Wolter and
                      T.-W. Kang$^*$ and N. A. Schmacke and A. Bridgeman and J.
                      Rehwinkel and L. Zender$^*$ and A. Ablasser},
      title        = {{I}nnate immune sensing of cytosolic chromatin fragments
                      through c{GAS} promotes senescence.},
      journal      = {Nature cell biology},
      volume       = {19},
      number       = {9},
      issn         = {1476-4679},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {DKFZ-2017-04051},
      pages        = {1061 - 1070},
      year         = {2017},
      abstract     = {Cellular senescence is triggered by various distinct
                      stresses and characterized by a permanent cell cycle arrest.
                      Senescent cells secrete a variety of inflammatory factors,
                      collectively referred to as the senescence-associated
                      secretory phenotype (SASP). The mechanism(s) underlying the
                      regulation of the SASP remains incompletely understood. Here
                      we define a role for innate DNA sensing in the regulation of
                      senescence and the SASP. We find that cyclic GMP-AMP
                      synthase (cGAS) recognizes cytosolic chromatin fragments in
                      senescent cells. The activation of cGAS, in turn, triggers
                      the production of SASP factors via stimulator of interferon
                      genes (STING), thereby promoting paracrine senescence. We
                      demonstrate that diverse stimuli of cellular senescence
                      engage the cGAS-STING pathway in vitro and we show
                      cGAS-dependent regulation of senescence following
                      irradiation and oncogene activation in vivo. Our findings
                      provide insights into the mechanisms underlying cellular
                      senescence by establishing the cGAS-STING pathway as a
                      crucial regulator of senescence and the SASP.},
      keywords     = {Chromatin (NLM Chemicals) / MPYS protein, mouse (NLM
                      Chemicals) / Membrane Proteins (NLM Chemicals) / MB21D1
                      protein, mouse (NLM Chemicals) / Nucleotidyltransferases
                      (NLM Chemicals)},
      cin          = {V076 / L801},
      ddc          = {570},
      cid          = {I:(DE-He78)V076-20160331 / I:(DE-He78)L801-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28759028},
      doi          = {10.1038/ncb3586},
      url          = {https://inrepo02.dkfz.de/record/128029},
}