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| Home > Publications database > Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis. > print |
| Home > Publications database > Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis. > print |
| 001 | 128038 | ||
| 005 | 20240228135042.0 | ||
| 024 | 7 | _ | |a 10.1007/s00395-014-0404-2 |2 doi |
| 024 | 7 | _ | |a pmid:24522833 |2 pmid |
| 024 | 7 | _ | |a 0175-9418 |2 ISSN |
| 024 | 7 | _ | |a 0300-8428 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2017-04060 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Manavski, Yosif |b 0 |
| 245 | _ | _ | |a Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis. |
| 260 | _ | _ | |a Berlin |c 2014 |b Springer65829 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1507203981_8664 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a β1-Integrins are essential for angiogenesis. The mechanisms regulating integrin function in endothelial cells (EC) and their contribution to angiogenesis remain elusive. Brag2 is a guanine nucleotide exchange factor for the small Arf-GTPases Arf5 and Arf6. The role of Brag2 in EC and angiogenesis and the underlying molecular mechanisms remain unclear. siRNA-mediated Brag2-silencing reduced EC angiogenic sprouting and migration. Brag2-siRNA transfection differentially affected α5β1- and αVβ3-integrin function: specifically, Brag2-silencing increased focal/fibrillar adhesions and adhesion on β1-integrin ligands (fibronectin and collagen), while reducing the adhesion on the αVβ3-integrin ligand, vitronectin. Consistent with these results, Brag2-silencing enhanced surface expression of α5β1-integrin, while reducing surface expression of αVβ3-integrin. Mechanistically, Brag2-mediated αVβ3-integrin-recycling and β1-integrin endocytosis and specifically of the active/matrix-bound α5β1-integrin present in fibrillar/focal adhesions (FA), suggesting that Brag2 contributes to the disassembly of FA via β1-integrin endocytosis. Arf5 and Arf6 are promoting downstream of Brag2 angiogenic sprouting, β1-integrin endocytosis and the regulation of FA. In vivo silencing of the Brag2-orthologues in zebrafish embryos using morpholinos perturbed vascular development. Furthermore, in vivo intravitreal injection of plasmids containing Brag2-shRNA reduced pathological ischemia-induced retinal and choroidal neovascularization. These data reveal that Brag2 is essential for developmental and pathological angiogenesis by promoting EC sprouting through regulation of adhesion by mediating β1-integrin internalization and link for the first time the process of β1-integrin endocytosis with angiogenesis. |
| 536 | _ | _ | |a 311 - Signalling pathways, cell and tumor biology (POF3-311) |0 G:(DE-HGF)POF3-311 |c POF3-311 |f POF III |x 0 |
| 542 | _ | _ | |i 2014-02-13 |2 Crossref |u http://www.springer.com/tdm |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Antigens, CD29 |2 NLM Chemicals |
| 650 | _ | 7 | |a Guanine Nucleotide Exchange Factors |2 NLM Chemicals |
| 650 | _ | 7 | |a IQSEC1 protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Integrin alphaVbeta3 |2 NLM Chemicals |
| 650 | _ | 7 | |a Integrin beta3 |2 NLM Chemicals |
| 650 | _ | 7 | |a RNA, Small Interfering |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, Vitronectin |2 NLM Chemicals |
| 650 | _ | 7 | |a VEGFA protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Vascular Endothelial Growth Factor A |2 NLM Chemicals |
| 650 | _ | 7 | |a integrin alphavbeta1 |2 NLM Chemicals |
| 650 | _ | 7 | |a ADP-Ribosylation Factors |0 EC 3.6.5.2 |2 NLM Chemicals |
| 650 | _ | 7 | |a ADP-ribosylation factor 6 |0 EC 3.6.5.2 |2 NLM Chemicals |
| 700 | 1 | _ | |a Carmona, Guillaume |b 1 |
| 700 | 1 | _ | |a Bennewitz, Katrin |b 2 |
| 700 | 1 | _ | |a Tang, Zhongshu |b 3 |
| 700 | 1 | _ | |a Zhang, Fan |b 4 |
| 700 | 1 | _ | |a Sakurai, Atsuko |b 5 |
| 700 | 1 | _ | |a Zeiher, Andreas M |b 6 |
| 700 | 1 | _ | |a Gutkind, J Silvio |b 7 |
| 700 | 1 | _ | |a Li, Xuri |b 8 |
| 700 | 1 | _ | |a Kroll, Jens |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Dimmeler, Stefanie |b 10 |
| 700 | 1 | _ | |a Chavakis, Emmanouil |b 11 |
| 773 | 1 | 8 | |a 10.1007/s00395-014-0404-2 |b Springer Science and Business Media LLC |d 2014-02-13 |n 2 |p 404 |3 journal-article |2 Crossref |t Basic Research in Cardiology |v 109 |y 2014 |x 0300-8428 |
| 773 | _ | _ | |a 10.1007/s00395-014-0404-2 |g Vol. 109, no. 2, p. 404 |0 PERI:(DE-600)1458470-0 |n 2 |p 404 |t Basic research in cardiology |v 109 |y 2014 |x 0300-8428 |
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| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 9 |6 P:(DE-HGF)0 |
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