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@ARTICLE{Hillengass:128061,
      author       = {J. Hillengass$^*$ and L. A. Moulopoulos and S. Delorme$^*$
                      and V. Koutoulidis and J. Mosebach$^*$ and T. Hielscher$^*$
                      and M. Drake and S. V. Rajkumar and B. Oestergaard and N.
                      Abildgaard and M. Hinge and T. Plesner and Y. Suehara and K.
                      Matsue and N. Withofs and J. Caers and A. Waage and H.
                      Goldschmidt$^*$ and M. A. Dimopoulos and S. Lentzsch and B.
                      Durie and E. Terpos},
      title        = {{W}hole-body computed tomography versus conventional
                      skeletal survey in patients with multiple myeloma: a study
                      of the {I}nternational {M}yeloma {W}orking {G}roup.},
      journal      = {Blood cancer journal},
      volume       = {7},
      number       = {8},
      issn         = {2044-5385},
      address      = {London [u.a.]},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2017-04083},
      pages        = {e599 -},
      year         = {2017},
      abstract     = {For decades, conventional skeletal survey (CSS) has been
                      the standard imaging technique for multiple myeloma (MM).
                      However, recently whole-body computed tomography (WBCT) has
                      been implemented into the diagnostic criteria of MM. This
                      analysis compares sensitivity and prognostic significance of
                      WBCT and CSS in patients with smoldering MM (SMM) and MM.
                      Fifty-four of 212 patients $(25.5\%)$ had a negative CSS and
                      a positive WBCT for osteolytic lesions (P<0.0001). Of 66
                      patients with SMM based on CSS, 12 $(22.2\%)$ had osteolytic
                      lesions on WBCT. In comparison, WBCT failed to detect some
                      bone destructions in the appendicular skeleton possibly due
                      to limitations of the field of view. Presence of lytic bone
                      lesions in WBCT was of borderline prognostic significance
                      (P=0.051) for SMM patients, with a median time to
                      progression of 38 versus 82 months for those without bone
                      destructions. In conclusion, WBCT identifies significantly
                      more sites of bone destruction than CSS. More than $20\%$ of
                      patients with SMM according to CSS have in fact active MM
                      detectable with WBCT. On the basis of this and other
                      studies, WBCT (either computed tomography (CT) alone or as
                      part of a positron emission tomography-CT protocol) should
                      be considered the current standard for the detection of
                      osteolytic lesions in MM.},
      cin          = {E010 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28841211},
      pmc          = {pmc:PMC5596388},
      doi          = {10.1038/bcj.2017.78},
      url          = {https://inrepo02.dkfz.de/record/128061},
}