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000128080 1001_ $$0P:(DE-He78)3ca4e0a81d07c5f9bf4a6fdbd176ebbb$$aLaudato, Sara$$b0$$eFirst author$$udkfz
000128080 245__ $$aP53-induced miR-30e-5p inhibits colorectal cancer invasion and metastasis by targeting ITGA6 and ITGB1.
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000128080 520__ $$aThe tumor suppressor P53 is a critical regulator of normal cellular homeostasis whose function is either distorted or lost in several cancer types including colorectal cancer (CRC). A small group of microRNAs have come to be recognized as essential mediators of P53 function. In a genome-wide systematic approach, we explored miRNAs that are substantially altered by P53 loss and found miR-30e to be the most significantly deregulated miRNA in P53-knockout human CRC cells. We identified miR-30e-5p to be a novel direct transcriptional target of P53 with gain and loss of function experiments revealing miR-30e-5p to be a significant regulator of tumor cell migration, invasion and in vivo metastasis mediated in part by integrins alpha-6 and beta-1 as novel targets. MiR-30e-5p also significantly reduced tumor cell proliferation by causing G1/S cell cycle arrest, which was achieved by inducing P21 and P27 expression. Finally, we found miR-30e-5p to be lost in resected CRC tumors as compared to normal colon tissues. Taken together, miR-30e-5p is a novel effector of P53-induced suppression of migration, invasion and metastasis.
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000128080 7001_ $$0P:(DE-He78)e22573706cfe9748cc0e45a526c2bfef$$aPatil, Nitin Shaligram$$b1$$udkfz
000128080 7001_ $$0P:(DE-He78)54a8723466e5d487247f3d93d51c66bc$$aAbba, Mohammed Lawan$$b2$$udkfz
000128080 7001_ $$0P:(DE-HGF)0$$aLeupold, Joerg H$$b3
000128080 7001_ $$0P:(DE-He78)e15dfa1260625c69d6690a197392a994$$aBenner, Axel$$b4$$udkfz
000128080 7001_ $$aGaiser, Timo$$b5
000128080 7001_ $$aMarx, Alexander$$b6
000128080 7001_ $$00000-0003-2192-5101$$aAllgayer, Heike$$b7$$eLast author
000128080 773__ $$0PERI:(DE-600)1474822-8$$a10.1002/ijc.30854$$gVol. 141, no. 9, p. 1879 - 1890$$n9$$p1879 - 1890$$tInternational journal of cancer$$v141$$x0020-7136$$y2017
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