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@ARTICLE{Laudato:128080,
      author       = {S. Laudato$^*$ and N. S. Patil$^*$ and M. L. Abba$^*$ and
                      J. H. Leupold$^*$ and A. Benner$^*$ and T. Gaiser and A.
                      Marx and H. Allgayer$^*$},
      title        = {{P}53-induced mi{R}-30e-5p inhibits colorectal cancer
                      invasion and metastasis by targeting {ITGA}6 and {ITGB}1.},
      journal      = {International journal of cancer},
      volume       = {141},
      number       = {9},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2017-04102},
      pages        = {1879 - 1890},
      year         = {2017},
      abstract     = {The tumor suppressor P53 is a critical regulator of normal
                      cellular homeostasis whose function is either distorted or
                      lost in several cancer types including colorectal cancer
                      (CRC). A small group of microRNAs have come to be recognized
                      as essential mediators of P53 function. In a genome-wide
                      systematic approach, we explored miRNAs that are
                      substantially altered by P53 loss and found miR-30e to be
                      the most significantly deregulated miRNA in P53-knockout
                      human CRC cells. We identified miR-30e-5p to be a novel
                      direct transcriptional target of P53 with gain and loss of
                      function experiments revealing miR-30e-5p to be a
                      significant regulator of tumor cell migration, invasion and
                      in vivo metastasis mediated in part by integrins alpha-6 and
                      beta-1 as novel targets. MiR-30e-5p also significantly
                      reduced tumor cell proliferation by causing G1/S cell cycle
                      arrest, which was achieved by inducing P21 and P27
                      expression. Finally, we found miR-30e-5p to be lost in
                      resected CRC tumors as compared to normal colon tissues.
                      Taken together, miR-30e-5p is a novel effector of
                      P53-induced suppression of migration, invasion and
                      metastasis.},
      cin          = {G360 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)G360-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28656629},
      doi          = {10.1002/ijc.30854},
      url          = {https://inrepo02.dkfz.de/record/128080},
}