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@ARTICLE{Lophatananon:128088,
      author       = {A. Lophatananon and S. Stewart-Brown and Z. Kote-Jarai and
                      A. A. A. Olama and S. B. Garcia and D. E. Neal and F. C.
                      Hamdy and J. L. Donovan and G. G. Giles and L. M. Fitzgerald
                      and M. C. Southey and P. Pharoah and N. Pashayan and H.
                      Gronberg and F. Wiklund and M. Aly and J. L. Stanford and H.
                      Brenner$^*$ and A. K. Dieffenbach$^*$ and V. Arndt$^*$ and
                      J. Y. Park and H.-Y. Lin and T. Sellers and C. Slavov and R.
                      Kaneva and V. Mitev and J. Batra and A. Spurdle and J. A.
                      Clements and D. Easton and R. A. Eeles and K. Muir},
      collaboration = {A. BioResource and P. consortium},
      title        = {{H}eight, selected genetic markers and prostate cancer
                      risk: results from the {PRACTICAL} consortium.},
      journal      = {British journal of cancer},
      volume       = {117},
      number       = {5},
      issn         = {1532-1827},
      address      = {Edinburgh},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2017-04110},
      pages        = {734 - 743},
      year         = {2017},
      abstract     = {Evidence on height and prostate cancer risk is mixed,
                      however, recent studies with large data sets support a
                      possible role for its association with the risk of
                      aggressive prostate cancer.We analysed data from the
                      PRACTICAL consortium consisting of 6207 prostate cancer
                      cases and 6016 controls and a subset of high grade cases
                      (2480 cases). We explored height, polymorphisms in genes
                      related to growth processes as main effects and their
                      possible interactions.The results suggest that height is
                      associated with high-grade prostate cancer risk. Men with
                      height >180 cm are at a $22\%$ increased risk as compared
                      to men with height <173 cm (OR 1.22, $95\%$ CI 1.01-1.48).
                      Genetic variants in the growth pathway gene showed an
                      association with prostate cancer risk. The aggregate scores
                      of the selected variants identified a significantly
                      increased risk of overall prostate cancer and high-grade
                      prostate cancer by $13\%$ and $15\%,$ respectively, in the
                      highest score group as compared to lowest score group.There
                      was no evidence of gene-environment interaction between
                      height and the selected candidate SNPs.Our findings suggest
                      a role of height in high-grade prostate cancer. The effect
                      of genetic variants in the genes related to growth is seen
                      in all cases and high-grade prostate cancer. There is no
                      interaction between these two exposures.},
      cin          = {C070 / G110 / L101 / C071},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331 /
                      I:(DE-He78)L101-20160331 / I:(DE-He78)C071-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28765617},
      pmc          = {pmc:PMC5572182},
      doi          = {10.1038/bjc.2017.231},
      url          = {https://inrepo02.dkfz.de/record/128088},
}