%0 Journal Article
%A Luft, Thomas
%A Benner, Axel
%A Jodele, Sonata
%A Dandoy, Christopher E
%A Storb, Rainer
%A Gooley, Ted
%A Sandmaier, Brenda M
%A Becker, Natalia
%A Radujkovic, Aleksandar
%A Dreger, Peter
%A Penack, Olaf
%T EASIX in patients with acute graft-versus-host disease: a retrospective cohort analysis.
%J The lancet  / Haematology
%V 4
%N 9
%@ 2352-3026
%C London [u.a.]
%I Elsevier
%M DKFZ-2017-04114
%P e414 - e423
%D 2017
%X Endothelial dysfunction links thrombotic microangiopathy to steroid-refractory graft-versus-host disease (GVHD) after allogeneic stem-cell transplantation. We aimed to assess if the simple formula-lactate dehydrogenase (U/L) × creatinine (mg/dL)/thrombocytes (10(9) cells per L)-termed the Endothelial Activation and Stress Index (EASIX), might be valuable for the prediction of death in patients with acute GVHD after allogeneic stem-cell transplantation.For this retrospective analysis, we analysed a training cohort (in Germany) and three validation cohorts (in Germany and the USA) of patients with acute GVHD who had received consecutive allogeneic stem-cell transplantation. The primary endpoint was prediction of overall survival when measured at acute GVHD onset (EASIX-GVHD). We validated the prognostic strength of EASIX-GVHD for overall survival and non-relapse mortality in the three independent cohorts by calculating the prediction error (integrated Brier score), and concordance index.In the total cohort of patients with acute GVHD (n=311), EASIX-GVHD predicted overall survival in univariable and multivariable models (univariate analysis, hazard ratio [HR] for a one-fold increase 1·16, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28733186
%R 10.1016/S2352-3026(17)30108-4
%U https://inrepo02.dkfz.de/record/128092